Correlation between serum Metrnl and interleukin-6 in patients with acute cerebral infarction
10.19845/j.cnki.zfysjjbzz.2021.0232
- VernacularTitle:急性脑梗死患者血清流星素和白介素6的相关性研究
- Author:
Zeheng LI
1
;
Guiyun CUI
1
;
Jie SUN
1
Author Information
1. Xuzhou Medical University,Xuzhou 221000,China
- Publication Type:Journal Article
- Keywords:
Metrnl;
Acute cerebral infarction;
IL-6;
Inflammatory reaction;
Atherosclerosis
- From:
Journal of Apoplexy and Nervous Diseases
2021;38(10):1060-1064
- CountryChina
- Language:Chinese
-
Abstract:
Objective As a new adipokine,Metrnl is closely related to atherosclerosis and inflammatory response.This study aims to explore the correlation between serum Metrnl level and acute cerebral infarction and inflammatory factors.Methods 139 patients with acute ischemic stroke were selected as ACI group,and 130 people with physical examination were selected as N-ACI group.The serum Metrnl level was measured by ELISA,and the common risk factors of stroke were detected.The correlation between serum Metrnl level and acute cerebral infarction and common risk factors was compared by statistical methods.Results The level of serum Metrnl in patients with ACI was lower than that in the control group (P<0.001).After adjusting for confounding factors,the difference was still significant,indicating that low level of Metrnl was significantly correlated with acute cerebral infarction.In the acute cerebral infarction group,the level of serum Metrnl was negatively correlated with BMI,HCY,LDL,AIP,and was negatively correlated with inflammatory markers Hs-CRP and IL-6.Regression analysis showed that Metrnl was a protective factor for acute cerebral infarction.Conclusion The level of serum Metrnl is significantly correlated with the occurrence of acute cerebral infarction.At the same time,the level of serum Metrnl is negatively correlated with inflammatory factor IL-6.As a new biomarker of acute cerebral infarction,Metrnl may become a new diagnostic and therapeutic target.
- Full text:2024072908571356419Correlation between serum Metrnl and interleukin-6 in patients with acute cerebral infarction.pdf
