Research progress on the intervention of traditional Chinese medicine in renal interstitial fibrosis based on PI3K/Akt signaling pathway
- VernacularTitle:中药通过PI3K/Akt信号通路干预肾间质纤维化的研究进展
- Author:
Xue LI
1
,
2
;
Yunlong ZHANG
3
;
Ziyi SONG
4
;
Zhujiang ZHANG
3
;
Chao YANG
5
;
Tianjiao REN
3
;
Linzhen JIA
6
Author Information
1. School of Basic Medicine，Qiqihar Medical College，Heilongjiang Qiqihar 161006，China
2. Heilongjiang Provincial Key Laboratory of Medicine-Food Homologous Resources and Metabolic Disease Prevention and Control，Heilongjiang Qiqihar 161006，China
3. School of Public Health，Qiqihar Medical College，Heilongjiang Qiqihar 161006，China
4. School of Stomatology，Qiqihar Medical College，Heilongjiang Qiqihar 161006，China
5. School of Medical Technology，Qiqihar Medical College，Heilongjiang Qiqihar 161006，China
6. School of Pharmacy，Qiqihar Medical College，Heilongjiang Qiqihar 161006，China
- Publication Type:Journal Article
- Keywords:
traditional Chinese medicine;
PI3K/Akt signaling pathway;
renal interstitial fibrosis;
action of mechanism
- From:
China Pharmacy
2024;35(14):1795-1800
- CountryChina
- Language:Chinese
-
Abstract:
Renal interstitial fibrosis（RIF） is the main pathological manifestation of chronic kidney disease. Due to the complexity of the mechanism， there is no specific treatment for RIF in clinical practice. The abnormal activation of the phosphatidylinositol 3-kinase （PI3K）/protein kinase B（Akt） signaling pathway and the activation of downstream target genes are key drivers of RIF induction and progression. Traditional Chinese medicine has the characteristics of precise efficacy and minimal toxic side effects， and the occurrence and development of RIF can be regulated by multiple targets and mutual coordination. This review focuses on the PI3K/Akt signaling pathway and summarizes the potential targets and regulatory mechanisms of traditional Chinese medicine in the treatment of RIF. It is found that various effective ingredients （such as sinomenine， mangiferin， coumarin derivates from Hydrangea paniculata， etc.） and formulas （such as Fushengong decoction， Qi-Bang-Yi-Shen formula， etc.） of traditional Chinese medicine can inhibit fibroblast proliferation， improve inflammation and oxidative stress， maintain mitochondrial stability， and slow down ferroptosis through this pathway， thereby delaying the occurrence and progression of RIF.
