Distribution and comparison of warfarin drug-gene polymorphism in Han children from Beijing area
- VernacularTitle:北京地区汉族儿童华法林药物基因多态性的分布与比较
- Author:
Xiaomei MA
1
,
2
;
Mingming ZHANG
1
;
Hongmao WANG
1
;
Li MENG
1
;
Xiaohui LI
1
Author Information
1. Dept. of Cardiovascular Medicine，Children’s Hospital Affiliated to Capital Institute of Pediatrics，Beijing 100020，China
2. Dept. of Cardiovascular Medicine，Teaching Hospital of Peking University Capital Institute of Pediatrics，Beijing 100020，China
- Publication Type:Journal Article
- Keywords:
warfarin;
gene polymorphism;
pharmacogenomics;
children;
pharmacogenetics
- From:
China Pharmacy
2024;35(14):1759-1764
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To analyze the distribution characteristics of warfarin drug-gene polymorphism in Han children from Beijing area. METHODS Data of nine warfarin drug-gene loci about VKORC1 rs9923231， CYP2C9 rs1799853*2 and rs1057910*3， CYP4F2 rs2108622， APOE rs429358 and rs7412， ABCB1 rs1045642， EPHX1 rs1051740 and rs2234922 were collected from dept. of cardiovascular medicine， Children’s Hospital Affiliated to Capital Institute of Pediatrics from March 2019 to March 2023， and the population data reported in domestic and foreign literature were compared. RESULTS In Beijing area， the frequency of APOE rs429358 mutant genotype was higher in males （19.8%） than in females （13.5%）（P＜0.05）. VKORC1 rs9923231 was dominated by homozygous mutant genotype （83.3%）， which was consistent with children in Japan （82.2%）， and higher than that of predominantly Caucasian children in the UK， Sweden， the United States， and Germany （10.4%-18.3%）（P＜ 0.05）； CYP2C9 was dominated by *1/*1 type （91.9%）， which was consistent with children in Japan （94.6%）， and higher than that of predominantly Caucasian children in the UK， Sweden， the United States， and Germany （66.1%-73.4%）（P＜0.05）. The frequency of EPHX1 rs1051740 mutant genotype was higher in adults （78.5%） than in children （63.5%）（P＜0.05）. CONCLUSIONS More mutations of VKORC1 rs9923231 and ABCB1 rs1045642 are found in Han children from Beijing area. The distribution of warfarin drug-gene polymorphisms in Han children from Beijing area is different among different genders， as well as compared with other countries， and Chinese Han adults. Therefore， caution should be exercised when using the reported data.
