Analysis of clinical characteristics and surgical outcomes of temporal lobe epilepsy patients with different auras
- VernacularTitle:不同发作先兆的颞叶癫痫患者临床特征及手术疗效分析
- Author:
Huanfa LI
1
;
Qiang MENG
1
;
Yong LIU
1
Author Information
- Publication Type:Journal Article
- Keywords: Temporal lobe epilepsy; Aura; Surgical outcomes; Febrile seizures; IEDs
- From: Journal of Apoplexy and Nervous Diseases 2021;38(11):990-993
- CountryChina
- Language:Chinese
- Abstract: To compared the clinical characteristics and surgical outcomes of temporal lobe epilepsy （TLE） patients with different auras，so as to provide more theoretical reference for the clinical diagnosis and treatment of TLE. Methods We retrospectively analyzed the clinical data of 408 TLE patients who underwent surgical treatment. The auras were divided into mesial temporal auras，lateral temporal auras，extratemporal auras and unspecific auras，and the age at seizure onset，gender，febrile seizures （FS），MRI，distribution of interictal epileptiform discharges （IEDs），secondary general tonicclonic seizures （SGTCS），operation side and surgical outcomes were compared in patients with different auras. Results 60.8% （248/408） of the TLE patients had auras，of which 37.7% were medial temporal auras，7.6% were lateral temporal auras，4.7% were extratemporal auras and 10.8% were unspecific auras. There was no significant difference in age at onset，gender，febrile seizures，MRI，distribution of IEDs，SGTCS and operation side in patients with or without auras（all P>0.05）. However，among patients with auras，those with mesial temporal auras had higher odds of focal IEDs （57.1% vs. 43.6%，P=0.039），and those with extratemporal auras had higher odds of FS and left side surgery （52.1% vs. 21.8%，P=0.006 and 73.7% vs. 49.3%，P=0.041，respectively）. The mean postoperative follow-up was 41.5±22.9 months and 75.4% （254/337） of patients were seizure free. There was no statistical difference in surgical outcomes among patients with different type of auras or no auras（P=0.483）.Conclusion The clinical characteristics including FS，lateralization of epileptogenic focus and distribution of IEDs in TLE patients with different type of auras had certain differences.However，there was no difference in surgical outcomes among TLE patients with no aura or different type of auras.
- Full text:2024072822420130956Analysis of clinical characteristics and surgical outcomes of temporal lobe epilepsy patients with different auras.pdf
