Study on the relationship between plasma lipoprotein a concentration and acute ischemic stroke in young people in Xinjiang
- VernacularTitle: 血浆脂蛋白a浓度与新疆地区青年发生急性缺血性脑卒中的关联性研究
- Author:
Junxin KUANG
1
;
Alimu WUFUER
1
;
Dengfeng HAN
1
Author Information
- Publication Type:Journal Article
- Keywords: cold stress； RNA-seq ；Dongxiang wild rice ； CRISPR/Cas9 genome editing technique
- From: Journal of Apoplexy and Nervous Diseases 2021;38(11):964-970
- CountryChina
- Language:Chinese
- Abstract: To investigate the relationship between plasma lipoprotein a concentration and acute ischemic stroke in young people in Xinjiang.Methods 316 young acute ischemic stroke patients who were hospitalized in the Neurology Center of the First Affiliated Hospital of Xinjiang Medical University from July 2016 to December 2020 were selected as the young stroke group，and 637 young nonstroke patients hospitalized during the same period were randomly selected As a youth nonstroke group. The medical history and clinical data of all subjects were collected，and the relationship between plasma lipoprotein a concentration and the occurrence of acute ischemic stroke in young people was analyzed. Results The plasma lipoprotein a concentration in the youth stroke group［140.55 （208.88）］was significantly higher than that in the youth nonstroke group［95.00 （151.38）］.Comparing the plasma lipoprotein a concentration of the young stroke group and the young nonstroke group according to ethnicity，whether it is Han，Uygur or Kazakh，the plasma lipoprotein a concentration of the young stroke group is higher than that of the young non stroke group（P<0.05）. Multivariate logistic regression analysis indicated that lipoprotein a may be one of the independent risk factors for acute ischemic stroke in young people in Xinjiang（OR=1.601，95%CI 1.342～1.910，P<0.05）. Further explore the relationship between the concentration of plasma lipoprotein a and the occurrence of acute ischemic stroke in Han，Uygur，and Kazakh youths. It shows that the increase of lipoprotein a level in Han youth is significantly related to the occurrence of acute ischemic stroke in young people. 1.751 （95%CI 1.404～2.183，P<0.05）；with the increase of plasma lipoprotein a concentration，acute deficiency The risk of bloody stroke also further increased. The risk ratio of the study population at the highest quartile level to the study population at the lowest quartile level was 4.948 （95%CI 2.528～9.686，P<0.05）.However，in the Uygur and Kazakhs，there is no correlation between the concentration of lipoprotein a and the occurrence of acute ischemic stroke in young people.Conclusion The concentration of plasma lipoprotein a is associated with the occurrence of acute ischemic stroke in young people in Xinjiang. Further exploring the ethnic differences in the correlation，it is found that the plasma lipoprotein a concentration is closely related to the occurrence of acute ischemic stroke in the Han youth，and there is no correlation between the Uyghur and Kazakh youths.
- Full text:2024072822235254052Study on the relationship between plasma lipoprotein a concentration and acute ischemic stroke in young people in Xinjiang.pdf
