Expression and significance of NT-proBNP,GFAP and HIF-1α in inflammatory injury in patients with cerebral hemorrhage
10.19845/j.cnki.zfysjjbzz.2021.0293
- VernacularTitle: NT-proBNP、GFAP及HIF-1α在脑出血患者炎性损伤中的表达及意义
- Author:
Daile SHI
1
;
Jiying GAO
1
;
Lipeng YANG
1
Author Information
1. Department of Neurosurgery,the First Affiliated Hospital of Hebei North University,Zhangjiakou 075000,China
- Publication Type:Journal Article
- Keywords:
NT-proBNP ；GFAP ； HIF-1α ； Cerebral hemorrhage ； Inflammatory injury
- From:
Journal of Apoplexy and Nervous Diseases
2021;38(12):1099-1102
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate N terminal pro B type natriuretic peptide (NT-proBNP),glial fibrillary acidic protein (GFAP)and hypoxia inducible factor-1 (hypoxia inducible factor-1α,HIF-1α) expression and there significance in inflammatory injury in patients with cerebral hemorrhage.Methods We selected 80 patients with acute intracerebral hemorrhage treated in our hospital from January 2018 to December 2019 as the observation group and 80 healthy people who underwent physical examination in our hospital in the same period as the control group.After routine treatment,NT-proBNP,GFAP and HIF-1α in patients serum and cerebrospinal fluid were detectedα、Tumor necrosis factor-α(TNF-α) interleukin-6 (IL-6),and correlation analysis was carried out.Results NT-proBNP,GFAP and HIF-1α in serum and cerebrospinal fluid of patients in the observation group、TNF-α and IL-6 levels in the control group were higher than those in the control group (P<0.05).NT-proBNP,GFAP and HIF-1α in serum and cerebrospinal fluid of the observation group after treatment,as well as TNF-α and IL-6 levels were lower than those before treatment (P<0.05).NT-proBNP,GFAP and HIF-1α in serum and cerebrospinal fluid increased with the aggravation of the disease、TNF-α and IL-6 levels were positively correlated with the degree of intracerebral hemorrhage (P<0.05).NT-proBNP,GFAP and HIF-1α in serum and cerebrospinal fluid were associated with inflammatory injury in intracerebral hemorrhage.There was a significant positive correlation with IL-6 level (P<0.05).NT-proBNP,GFAP and HIF-1α.It was closely related to inflammatory injury in patients with intracerebral hemorrhage and was an independent risk factor for intracerebral hemorrhage complicated with inflammatory injury (P<0.05).Conclusion The levels of NT-proBNP,GFAP and HIF-1α are closely related to inflammatory injury and prognosis in patients with cerebral hemorrhage.The detection of NT-proBNP,GFAP and HIF-1α levels has certain clinical value in judging the disease and prognosis.
- Full text:2024072822163461435Expression and significance of NT-proBNP,GFAP and HIF-1α in inflammatory injury in patients with cerebral hemorrhage.pdf
