Retrospective analysis of subacute combined degeneration of spinal cord
10.19845/j.cnki.zfysjjbzz.2021.0289
- VernacularTitle:脊髓亚急性联合变性的回顾性分析
- Author:
Shaowei ZHENG
1
;
Ni YANG
1
;
Xin HONG
1
Author Information
1. Department of Emergency,The Second Affiliated Hospital of Xi an Jiaotong University，Xi an 710004，China
- Publication Type:Journal Article
- Keywords:
Subacute combined degeneration of spinal cord;
Vitamin B12;
Anemia
- From:
Journal of Apoplexy and Nervous Diseases
2021;38(12):1085-1087
- CountryChina
- Language:Chinese
-
Abstract:
Objective This study retrospectively analyzed reported cases of subacute combined degeneration of spinal cords(SCD).The purpose of this study was to provide theoretical basis for the prevention,diagnosis,treatment and research of SCD.Methods We searched the PubMed database for terms related to subacute combined degeneration of spinal cords from March 2,2019 to January 1,1990.255 cases were finally included in the study.Results The common causes of SCD were Vitamin B12 deficiency (128 cases),inhaled N-2O (70 cases) and copper deficiency (31 cases).The disease usually happened on middle-ager (44.5±19.9) years old.The course of the disease is relatively long (36.5±85.1) weeks.Limbs hypoesthesia was the most common symptom (73.3%),followed by ataxia (61.6%),and limb motor system could also be involved (35.3%).Autonomic nervous system,cranial nerve,consciousness disorder and cognitive disorder are rare.The patients were often complicated with giant cell anemia (72.5%) and hyperhomocysteinemia (80.9%).Spinal cord MR could show abnormal signal shadow in posterior cord (82.9%),most of which occurred in cervical cord.Conclusion Vitamin B12 deficiency was the most common cause of SCD in adults and N-2O abuse must be paid attention in young people.Most patients of SCD showed peripheral nervous system damage that sensory system damage is common.Abnormal signal shadow in posterior cord of spinal MR was specific for the diagnosis of SCD.Most patients with SCD have a good prognosis after treatment.
- Full text:2024072822044090030Retrospective analysis of subacute combined degeneration of spinal cord.pdf
