Correlation between free fatty acid metabonomics in patients with acute cerebral infarction
- VernacularTitle:急性脑梗死患者的脂肪酸代谢组学相关性分析
- Author:
Shi TANG
1
;
Buxian TIAN
1
Author Information
- Publication Type:Journal Article
- Keywords: Cerebral infarction; Lipidomics; Tandem mass spectrometry; Free fatty acids
- From: Journal of Apoplexy and Nervous Diseases 2021;38(12):1081-1084
- CountryChina
- Language:Chinese
- Abstract: Objective To explore the relationship between free fatty acid metabolites and the acute cerebral infarction based on tandem mass spectrometry.Methods Collecting 460 objects admitted to the first affiliated hospital of jinzhou medical university from October 2019 to January 2020.According to the presence of new cerebral infarction in the head imaging examination，they were divided into two groups：acute cerebral infarction group and control group.The tandem mass spectrometry was used to detect plasma 25 free fatty acids metabolites.Orthogonal partial least squares discriminant analysis (OPLS-DA)，Receiver operating characteristic curve (ROC) and logistic regression were used to screen the differential metabolites.Results There are 5 free fatty acid metabolites and the comprehensive indicators W significantly correlated with the incidence of cerebral infarction.The area under curve (AUC) of each metabolite for predicting cerebral infarction was as follows：W (0.917)，palmitic acid (0.892)，stearic acid (0.878)，linoleic acid (0.864)，oleic acid (0.840)，arachidonic acid (0.806).Conclusion Linoleic acid，palmitic acid，stearic acid，arachidonic acid，oleic acid may be related to the occurrence and development of cerebral infarction，and the study of their metabolic processes may provide a basis for exploring the pathogenesis of cerebral infarction.
- Full text:2024072822020817080Correlation between free fatty acid metabonomics in patients with acute cerebral infarction.pdf
