The clinical value of variation coefficient and standard deviation of erythrocyte distribution width in diagnosis of colorectal cancer metastasis
10.19405/j.cnki.issn1000-1492.2023.04.030
- Author:
Shuomin Wang
1
,
2
;
Yong Zhu
1
,
3
;
Yunhong Xia
1
,
2
Author Information
1. Dept of Oncology，The First Affiliated Hospital of Anhui Medical University，Hefei 230012
2. Dept of Oncology，Anhui Public Health Clinical Center，Hefei 230012
3. Dept of General Surgery，Anhui Public Health Clinical Center，Hefei 230012
- Publication Type:Journal Article
- Keywords:
colorectal cancer;
metastasis;
coefficient of variation of erythrocyte distribution width;
standard devia- tion of erythrocyte distribution width
- From:
Acta Universitatis Medicinalis Anhui
2023;58(4):698-701
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the clinical value of coefficient of variation ( RDW-CV) and standard deviation (RDW-SD) of erythrocyte distribution width in the diagnosis of colorectal cancer ( CRC) metastasis．
Methods :91 CRC inpatients were selected as the research subjects．According to whether the tumor was metastatic，they were divided into two groups : 61 cases in the non-metastatic group and 30 cases in the metastasis group．The laboratory indicators of the two groups of patients included : neutrophils count，lymphocyte count，platelet count，carcinoembryonic antigen，plasma prothrombin time，activated partial thromboplastin time，fibrinogen，thrombin time， RDW-CV and RDW-SD and other indicators．The t test was used to compare the means of the two groups，and the pearson correlation was used to analyze the relationship between RDW-CV and RDW-SD with neutrophil count， lymphocyte count，neutrophil count-lymphocyte count ratio (NLR) and carcinoembryonic antigen．Correlation coefficient，receiver operating characteristic curve ( ROC) to assess the area under the curve ( AUC) of RDW-CV， RDW-SD，carcinoembryonic antigen and their combined diagnosis in assessing CRC metastasis.
Results:Compared with non-metastatic patients，the RDW-CV and RDW-SD values of metastatic patients were higher (both P < 0. 05) ．Both RDW-CV and RDW-SD levels were positively correlated with carcinoembryonic antigen content．Compared with the AUC of carcinoembryonic antigen in diagnosis of CRC metastasis，the AUC of RDW-CV or RDW-SD combined with carcinoembryonic antigen was higher．
Conclusion:RDW-CV and RDW-SD have potential clinical application value in differential diagnosis of CRC metastasis.
- Full text:2024072720344039752红细胞分布宽度变异系数及标...直肠癌转移诊断中的临床价值_汪硕敏.pdf
