Feasibility of evaluating coronary artery calcium score on virtual non-contrast scan in dual-layer spectral detector CT

Panpan Yang; Lu Lu; Mao Sheng; Ruomei Li; Ji Zhang; Yuqi Jiang; Xinna Zhang; Wei Deng; Yuguo Li; Shutian An; Ren Zhao; Yongqiang Yu; Xiaohu Li

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Feasibility of evaluating coronary artery calcium score on virtual non-contrast scan in dual-layer spectral detector CT

Author: Panpan Yang ¹ ; Lu Lu ^{2
,

3} ; Mao Sheng ^{2
,

3} ; Ruomei Li ^{2
,

3} ; Ji Zhang ^{2
,

3} ; Yuqi Jiang ¹ ; Xinna Zhang ⁴ ; Wei Deng ⁴ ; Yuguo Li ⁴ ; Shutian An ⁴ ; Ren Zhao ⁵ ; Yongqiang Yu ⁴ ; Xiaohu Li ^{1
,

4}
Author Information

1. Dept of Radiology，Fuyang Hospital of Anhui Medical University，Fuyang 236000
2. Dept of Radiology， The Second People '
3. s Hospital of Hefei，Hefei Hospital of Anhui Medical University，Hefei 230011
4. Dept of Radiology，The First Affiliated Hospital of Anhui Medical University，Hefei 230022
5. Dept of Cardiology，The First Affiliated Hospital of Anhui Medical University，Hefei 230022
Publication Type:Journal Article
Keywords: calcium score; coronary artery disease; virtual non-contrast
From: Acta Universitatis Medicinalis Anhui 2023;58(4):692-697
CountryChina
Language:Chinese
Abstract: Objective:To evaluate the accuracy and feasibility of coronary artery calcium score ( CACS) on virtual non-contrast scan ( VNC) images obtained from coronary artery CT angiography ( CCTA) scan with dual －layer spectral detector CT (SDCT) ．
Methods :The data of 197 patients who underwent CCTA scan in hospital were analyzed retrospectively，and 88 patients with CACS ＞0 were further analyzed． Linear regression analysis of CACS and coronary artery calcium volume ( CACV) of true non-contrast (TNC) images and VNC images ( CACS-TNC， CACS-VNC，CACV-TNC，CACV-VNC) was performed to obtain linear regression equation and correction coefficients λ 1AVG and λ2AVG ．CACS-VNC and CACV-VNC were corrected by the corresponding regression equation and recorded as CCACS-VNC and CCACV-VNC，respectively．Spearman correlation coefficient was used for correlation analysis and Bland-Altman plot was used for consistency test．Mann-Whitney U test was used to compare the difference between the two groups.
Results :For the total coronary artery，there was a strong correlation between CACS- TNC and CACS-VNC (rs = 0. 952，P ＜0. 001 ，λ 1AVG = 2. 19 ) ，CACV-TNC and CACV-VNC ( rs = 0. 954，P < 0. 001，λ2AVG = 1. 93) ．The results of Mann-Whitney U test showed that there was no significant difference between CACS-TNC and CCACS-VNC or between CACV-TNC and CCACV-VNC，and the Bland-Altman plot showed good consistency between CACS-TNC and CCACS-VNC ，CACV-TNC and CCACV-VNC．
Conclusion:VNC images based on SDCT can accurately measure CACS and be used for cardiovascular risk classification，which is expected to replace TNC scan and reduce the radiation dose of patients.
Full text:202407272028375423双层探测器光谱CT虚拟平扫...估冠状动脉钙化积分的可行性_杨盼盼.pdf