Research progress in porcine reproductive and respiratory syndrome virus and vaccine against it

VernacularTitle:猪繁殖与呼吸综合征病毒及其疫苗的研究进展
Author: DU Yanbin
Publication Type:Journal Article
Keywords: Porcine reproductive and respiratory syndrome virus(PRRSV); Immune mechanism; Live attenuated vaccine; Inactivated vaccine
From: Chinese Journal of Biologicals 2024;37(07):881-886
CountryChina
Language:Chinese
Abstract: Porcine reproductive and respiratory syndrome(PRRS),also known as blue ear disease,is an immunosuppressive disease caused by porcine reproductive and respiratory syndrome virus(PRRSV). PRRSV is an important infectious pathogen of porcine,which has the characteristics of easy recombination and mutation,high transmission ability,and has been widely spread in the world. At the same time,because of the characteristics of immunosuppression,immune evasion,and easy-to-cause antibody-dependent enhancement(ADE),the pathogen has brought serious challenges to the disease prevention and control of PRRS and the development of related vaccines. In this paper,the pathogenic process of PRRSV,immune evasion mechanism,and research progress in different types of PRRSV vaccines were reviewed,in order to provide ideas for the development of related vaccines in the future