Atypical antipsychotic drugs with strong alpha 1 receptor antagonism resulting in self-perceived hot in patients with schizophrenia： a case report
10.11886/scjsws20240124001
- VernacularTitle:强α1受体拮抗的非典型抗精神病药物导致精神分裂症患者自感发热不适1例
- Author:
Linyuan SUN
1
;
Yang GAO
2
;
Bin SU
2
;
Mingli LI
1
Author Information
1. West China Hospital， Sichuan University， Chengdu 610041， China
2. Karamay Hospital of Integrated Traditional Chinese and Western Medicine， Karamay 834000， China
- Publication Type:Journal Article
- Keywords:
Schizophrenia;
Atypical antipsychotic drugs with strong alpha 1 receptor antagonism;
Fever
- From:
Sichuan Mental Health
2024;37(3):267-269
- CountryChina
- Language:Chinese
-
Abstract:
This article reported a case of a patient with schizophrenia who experienced self-perceived fever and discomfort after taking atypical antipsychotic drugs with strong alpha 1 receptor antagonism， which included olanzapine， risperidone， paliperidone and clozapine. Such phenomenon was believed to be a medication side effect. Therefore， the patient switched to aripiprazole and the fever disappeared. This case report is intended to remind psychiatrists to pay attention to the side effects caused by atypical antipsychotic drugs with strong alpha 1 receptor antagonism as well as to suggest that various factors should be considered， including mechanisms of drug action， patient pathophysiology and individual differences， in order to improve treatment compliance and prognosis.
