Effect of cerebral small vessel disease on the progress of acute stage of large artery atherosclerotic cerebral infarction
10.19845/j.cnki.zfysjjbzz.2022.0029
- VernacularTitle:脑小血管病总负荷对大动脉粥样硬化型脑梗死急性期病情进展的影响
- Author:
Qiangbin LU
1
;
Yanyan BAI
1
;
Jiangfang MIAO
1
Author Information
1. Department of Neurology,Jiangyin Hospital Affiliated to Nantong University,Jiangyin 214400,China
- Publication Type:Journal Article
- Keywords:
Large artery atherosclerosis cerebral infarction;
Cerebral small vessel disease;
Total load score;
Progress
- From:
Journal of Apoplexy and Nervous Diseases
2022;39(2):123-126
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between the total burden of cerebral small vessel disease (CSVD) and the progression of large artery atherosclerosis (LAA) cerebral infarction in acute stage.Methods One hundred and forty-three patients with acute LAA cerebral infarction were collected.The CSVD total load score (0~4 points) was calculated according to MRI and CSVD total load scale.According to the progress of the disease in the acute phase,the patients were divided into two groups:non progressive cerebral infarction group (NPCI) and progressive cerebral infarction group (PCI).The baseline data,CSVD sub items and total load scores were compared between two groups.Logistic regression analysis was used to analyze the relationship between CSVD total load score and the progression of LAA type cerebral infarction.Results There was significant difference in CSVD total load score between PCI group and NPCI group (P<0.05).In group PCI,smoking history,diabetes history,baseline diastolic blood pressure,fasting blood glucose,vascular lacuna,moderate and severe WMH,CMBs and CSVD total load score were all higher than those in NPCI group (P<0.05),and LDL-C level was lower than that in NPCI group (P<0.05).Logistic regression analysis showed that fasting blood glucose,moderate and severe WMH and CSVD total load score were independent risk factors for the progression of LAA cerebral infarction in acute stage (P<0.05).Conclusion The severity of CSVD in patients with LAA type cerebral infarction is closely related to the progress of the disease in acute phase.
- Full text:2024072611475384316Effect of cerebral small vessel disease on the progress of acute stage of large artery atherosclerotic cerebral infarction.pdf
