The Study on the pathogenesis of migraine
10.19845/j.cnki.zfysjjbzz.2022.0067
- VernacularTitle:偏头痛发病相关机制的研究
- Author:
Yuyan HAO
1
;
Li YANG
1
;
Zheman XIAO
1
Author Information
1. Department of Neurology，People Hospital of Wuhan University，Wuhan 430060，China
- Publication Type:Journal Article
- Keywords:
Migraine;
Pain perception thresholds （PPT）;
Current perception thresholds （CPT）;
Pain tolerance thresholds （PTT）
- From:
Journal of Apoplexy and Nervous Diseases
2022;39(3):267-270
- CountryChina
- Language:Chinese
-
Abstract:
Abstract: Objective To explore the pain threshold, current perception threshold and pain tolerance threshold of migraine patients in the interpartial period of headache, so as to clarify their sensory sensitivity. Methods From September 2019 to June 2021 ,27 migraine patients and healthy subjects with matched age, gender and education level were collected in Department of Neurology, People’s Hospital of Wuhan University. During the interpartial period of migraine, the pain perception threshold (PPT) of the bilateral first trigeminal nerve and median nerve was measured by the Von Frey fiber, and the current perception thresholds (CPT) of the bilateral first trigeminal nerve and median nerve and the pain tolerance threshold(PTT) of the bilateral median nerve were recorded by sensory nerve quantitative detector. Results In our study, no significant statistical differences were found between PPT and CPT and healthy controls, but PTT values were significantly decreased compared with the control group. Conclusion The reduced threshold of pain tolerance during interpartial period may be related to central sensitization, which may be caused by abnormal sensory inputs of Aδ and C fibers.
- Full text:2024072611063521475The Study on the pathogenesis of migraine.pdf
