The Effects of Psychotropic Drugs on the beta-Amyloid-Induced Cytotoxicity in PC12 Cells.
- Author:
Tae Suk KIM
1
;
Chul LEE
;
Soo Jung LEE
;
Kyu Young TOH
;
Jung Jin KIM
;
In Ho PAIK
Author Information
1. Department of Psychiatry, College of medicine, Catholic University of Korea, Seoul
- Publication Type:In Vitro ; Original Article
- Keywords:
Psychotropic drug;
beta-amyloid protein;
Cytotoxicity;
PC12 cell
- MeSH:
Amitriptyline;
Amyloid;
Amyloid beta-Peptides;
Animals;
Chlorpromazine;
Dementia;
Depression;
Fluoxetine;
Haloperidol;
Moclobemide;
Neurons;
Neurotransmitter Agents;
PC12 Cells*;
Psychotropic Drugs*;
Rats;
Risperidone
- From:Journal of Korean Neuropsychiatric Association
2000;39(5):936-943
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: Amyloid beta protein(Abeta) has been regarded to be toxic to neurons in vitro. However, the mechanism of action leading to neuronal death remains unknown. In this study, we report the effects of psychotropic drugs, that are often prescribed for the improvement of psychotic and depressive symptoms in dementia of the Alzheimer's type, on the beta-amyloid-induced cytotoxicity in rat pheochromocytoma(PC12) cells. METHODS: We treated antipsychotics(chlorpromazine, haloperidol, and risperidone) and antidepressants(amitriptyline, fluoxetine, and moclobemide) at 0.1-10 microM concentrations before application of Abeta(10 microM), and compared with control in the absence of psychotropic drugs in cultured PC12 cells. RESULTS: 1) Chlorpromazine, haloperidol and risperidone significantly reduced Abeta-induced cytotoxicity in PC12 cells. 2) Amitriptyline, fluoxetine, and moclobemide significantly reduced Abeta-induced cytotoxicity in PC12 cells. CONCLUSION: Our results suggest that psychotropic drugs in the treatment of dementia of Alzheimer's type may protect the neural cells as well as control neurotransmitter activities.