Analysis of the incidence and influencing factors of liver fibrosis in patients with end-stage renal disease
10.19405/j.cnki.issn1000-1492.2022.11.026
- Author:
Shule Xie
1
;
Jin Zhang
1
;
Pei Zhang
1
;
Yonggui Wu
1
Author Information
1. Dept of Nephropathy，The First Affiliated Hospital of Anhui Medical University，Hefei 230022
- Publication Type:Journal Article
- Keywords:
end-stage renal disease;
liver fibrosis;
complement C4;
lactate dehydrogenase
- From:
Acta Universitatis Medicinalis Anhui
2022;57(11):1831-1835
- CountryChina
- Language:Chinese
-
Abstract:
Objective :To explore the occurrence and related factors of liver fibrosis in patients with End-stage re- nal disease (ESRD) ．
Methods :A total of 83 ESRD patients were included in the study．Transient elastography was used to diagnose whether hepatic fibrosis occurred or not．According to the occurrence of hepatic fibrosis or not，the included patients were divided into a non-hepatic fibrosis group(n = 37) and a hepatic fibrosis group(n = 46) ．The demographic data and clinical laboratory indexes of the two groups were compared．Statistically signifi- cant variables were selected and included in the multivariate Logistics stepwise regression analysis to explore the in- fluencing factors of liver fibrosis in ESRD patients.
Results :The prevalence of liver fibrosis in ESRD patients was 55. 42% ．Compared with the non-hepatic fibrosis group，the hepatic fibrosis group had lower white blood cells，e- rythrocyte sedimentation rate，complement C3 and C4(P＜0. 05) ．Multivariate Logistics analysis showed that com- plement C4 level ( OR = 0. 930，95% CI : 0. 872 －0. 992，P = 0. 028 ) and higher lactate dehydrogenase ( LDH) level ( OR = 1. 016，95% CI : 1. 005 －1. 027，P = 0. 004) were the independent influencing factors of liver fibrosis in ESRD patients．
Conclusion :The probability of liver fibrosis in ESRD patients is high．Serum complement C4 and LDH are independent influencing factors of liver fibrosis． Dynamic monitoring of serum complement C4 and LDH levels is conducive to target liver fibrosis in ESRD patients.
- Full text:2024072521593756699终末期肾脏病患者肝纤维化的发生及影响因素分析_谢书乐.pdf
