Relationship between serum mir-493 expression and prognosis after thrombolysis in patients with acute cerebral infarction
10.19845/j.cnki.zfysjjbzz.2022.0078
- VernacularTitle:脑梗死急性期患者血清miR-493表达水平及其与溶栓后预后的关系研究
- Author:
Meijuan KANG
1
;
Changming WEN
1
;
Baochao ZHANG
1
Author Information
1. Nanyang Central Hospital,Nanyang 47300,China
- Publication Type:Journal Article
- Keywords:
Cerebral infarction ； Acute phase ； MicroRNA-493 ； Thrombolytic therapy ； Prognosis
- From:
Journal of Apoplexy and Nervous Diseases
2022;39(4):306-309
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression level of serum microrna-493 (mir-493) in patients with acute cerebral infarction (ACI) and its relationship with the prognosis after thrombolysis.Methods Seventy patients with ACI in our hospital from October 2019 to March 2021 were selected as the study group,and 70 patients with healthy physical examination during the same period were selected as the control group.The serum miR-493 levels of the study group before treatment,3 d,7 d after treatment were detected.Results The serum miR-493 levels in the study group were higher than that before treatment at 3 days after treatment,however,the serum miR-493 levels in the study group were lower in each time period (P<0.05).Serum miR-493 levels before treatment and neurological deficits in ACI patients Degree,serum VEGF,Ang-2,CRP,and IL-6 levels were negatively correlated (P<0.05).Serum miR-493 levels before treatment,3 d,and 7 d after treatment in the study group with good prognosis were higher than those with poor prognosis patients (P<0.05).The area under the curve (AUC) of serum miR-493 predicting poor prognosis of ACI patients with thrombolytic therapy before treatment,3 d and 7 d after treatment were 0.748,0.851,0.879,respectively,and 7 d after treatment serum miR-493 predicted the largest AUC,and the best prediction sensitivity and specificity were 73.68% and 88.24%,respectively.Conclusion The expression levels of serum miR-493 in patients with acute cerebral infarction are significantly reduced,and related to the prognosis of patients after thrombolysis,and has certain value in assisting clinical prediction of the prognosis of patients.
- Full text:2024072520533845126Relationship between serum mir-493 expression and prognosis after thrombolysis in patients with acute cerebral infarction.pdf
