Retrospective cohort analysis of the relationship between correcting abnormal glucose metabolism and controlling the risk of death of digestive system malignant tumors
10.3969/j.issn.1006-2483.2024.04.021
- VernacularTitle:纠正糖代谢异常与消化系统恶性肿瘤死亡风险关联的回顾性队列研究
- Author:
Yun FAN
1
,
2
,
3
;
Jie CHI
1
,
2
,
3
;
Jinyi FAN
1
,
2
,
3
;
Yinkun WANG
1
,
2
,
3
;
Xiao ZHENG
1
,
2
,
3
Author Information
1. Department of Clinical Laboratory, Shaanxi Provincial People'
2. s Hospital , Xi'
3. an , Shaanxi 710068 , China
- Publication Type:Journal Article
- Keywords:
Glucose metabolism;
Malignant tumor of digestive system;
Death;
Cohort study
- From:
Journal of Public Health and Preventive Medicine
2024;35(4):87-90
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between correcting abnormal glucose metabolism and mortality risk of malignant tumors of digestive system. Methods A retrospective cohort study was conducted. 1308 patients with abnormal glucose metabolism in our hospital from January 2019 were divided into exposed group (n=777) and non-exposed group (n=531) according to the presence or absence of glucose metabolism correction therapy. The patients were retrospectively followed up until December 2022. The incidence of digestive system tumors and the influencing factors of tumors were compared between the two groups. Results There were 31 patients with digestive system tumor and 9 patients died. The incidence of digestive system tumors was lower in the exposed group (3/777) than in the non-exposed group (28/531). The mortality rate in the exposed group (1/777) was lower than that in the non-exposed group (8/531). Cox regression model analysis showed that correcting abnormal glucose metabolism was a protective factor for the risk of death from malignant tumors of the digestive system in patients (HR value<1, P<0.05) ; increased FBG, combined abnormal lipid metabolism, increased pulse pressure difference, family history of malignant tumors, and alcohol consumption were shown as risk factors for the risk of death from malignant tumors of the digestive system in patients (HR values>1, P<0.05). Conclusion Correcting abnormal glucose metabolism is of positive significance in reducing the risk of death from malignant tumors of digestive system. Patients with increased FBG, abnormal lipid metabolism, increased pulse pressure difference, family history of malignant tumors and alcohol consumption should pay special attention to correct abnormal glucose metabolism in time.
