Changes of laboratory biochemical indicators in HIV / AIDS patients treated with different antiviral regimens
10.3969/j.issn.1006-2483.2024.04.012
- VernacularTitle:不同抗病毒方案治疗HIV/AIDS患者实验室生化指标变化分析
- Author:
Mengxue LI
1
,
2
;
Jiafa LIU
1
;
Rui ZHANG
2
;
Zhixing WU
2
;
Jianjian LI
1
;
Xuemei DENG
1
;
Kailin YANG
1
;
Xingqi DONG
1
,
2
;
Mi ZHANG
1
Author Information
1. Department of Laboratory , Yunnan Provincial Infectious Diseases Hospital , Kunming , Yunnan 650301, China
2. School of Public Health , Kunming Medicine University , Kunming , Yunnan 650000 ,China
- Publication Type:Journal Article
- Keywords:
HIV/AIDS patients;
ART regimen;
Biochemical indicators
- From:
Journal of Public Health and Preventive Medicine
2024;35(4):49-52
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the changes of liver and kidney function, blood glucose and lipid metabolism at different follow-up time points of different treatment regimens, and to provide reference for clinical optimization and adjustment of medication in HIV/AIDS patients. Methods The changes of liver and kidney function, blood glucose and lipid metabolism at seven follow-up time points were analyzed retrospectively. The baseline blood collection time of HIV /AIDS patients was set as the starting point, and the final follow-up time was set as the end point. The seven follow-up points were 0, 3, 6, 9, 12, 18 and 24 months respectively. Results There were statistically significant differences in the distribution of sex, age, education, marital status, WHO staging, infection route, and baseline CD4+T lymphocyte count among 605 enrolled patients based on different treatment regimens. Liver function: The level of T-Bil in group E was higher than that of baseline at 9M, 12M, 18M and 24M after treatment (P<0.01); In group F, the level of T-Bil was higher than that of baseline at 9M after treatment (P=0.001); The levels of ALT in group C at the six follow-up points after treatment were higher than the baseline (P<0.001); The level of AST in group C was higher than that of baseline after 3M and 6M treatment (P<0.05). Renal function: The level of UREA in group C was higher than that in baseline after 6M treatment (P=0.007); The level of UREA in group F was higher than that in the baseline after 12M treatment (P<0.001); The level of UA in group F was higher than that of baseline after 3M, 6M and 12M treatment (P<0.05). Blood lipid and blood glucose: The levels of Glu at some follow-up points after ART treatment in group A and group C were higher than that at baseline (P<0.05); The levels of TG at some follow-up points in group A, group E and group F after ART treatment were higher than those at baseline (P<0.05); The levels of TC at some follow-up points in group A, group B, group C, group E and group F after ART treatment were all higher than the baseline (P<0.05). Conclusion Regular monitoring of changes in laboratory indicators of different treatment regimens during ART is of great importance to the prognosis of patients. Different laboratory indicators should be monitored according to different treatment regimens to effectively prevent adverse reactions caused by different treatment regimens.
