Identification of genetic characteristics of B19 virus in a human parvovirus outbreak
- VernacularTitle:鉴定一起人细小病毒疫情中B19病毒的基因特征
- Author:
Ting ZHANG
1
;
Qili ZENG
1
;
Kun CAI
1
Author Information
- Publication Type:Journal Article
- Keywords: Human parvovirus virus B19; Genotype; Nucleotide; Homology
- From: Journal of Public Health and Preventive Medicine 2024;35(4):45-48
- CountryChina
- Language:Chinese
- Abstract: Objective To analyze the genetic characteristics of B19 parvovirus in a human parvovirus outbreak in Hubei Province in 2019, and to provide scientific basis for the prevention and control of parvovirus outbreaks. Methods Among of the 17 serum specimens and 20 throat swab specimens from a parvovirus B19 outbreak were collected in Hubei Province in 2019. The nucleic acid-positive specimens were identified by fluorescence quantitative RT-PCR. The specific sequences of NS1-VP1u (1157 bp) of B19 positive specimens were amplified by nested PCR to determine B19 genotype. Results The genotype of B19 virus in 17 patients were subgenotype 1a, and the nucleotide homology of subgenotype 1a was 99.90% - 100%. The B19 subgenotype 1a was located in the same small branch as the Chinese Beijing strain KR819772, the Chinese Beijing strain KR819773 and the Chinese Hangzhou strain KT310174, and the distance was the closest. Conclusion The B19 virus in a human parvovirus outbreak in Hubei Province in 2019 belongs to subgenotype 1a.
