Progress of Research on ABC Transporters in Tumor Multidrug Resistance
10.3971/j.issn.1000-8578.2024.24.0082
- VernacularTitle:ABC转运蛋白在肿瘤多药耐药中的研究进展
- Author:
Xiaoke XING
1
;
Shuxian WANG
1
;
Juanjuan LI
1
;
Qibin SONG
1
;
Pingfeng ZHANG
1
Author Information
1. Cancer Center, Renmin Hospital of Wuhan University, Wuhan 430060, China.
- Publication Type:REVIEWS
- Keywords:
ABC transporter;
Transmembrane transport;
MDR;
Tumor
- From:
Cancer Research on Prevention and Treatment
2024;51(7):594-599
- CountryChina
- Language:Chinese
-
Abstract:
The ATP-binding cassette (ABC) transporter superfamily comprises membrane proteins that efflux various substrates across extra- and intracellular membranes. Among them, ABCB1, ABCG2, and ABCC1 are directly linked to tumor multidrug resistance (MDR). This review provides an overview of the current understanding on the novel mechanisms and functions of ABCB1, ABCG2, and ABCC1 transporters in tumor MDR, discusses the latest strategies to target these transporters, and explores further opportunities to overcome MDR.
