Causal Association Between Omega-3 Fatty Acids and Risk of Breast Cancer: A Mendelian Randomization Study
10.3971/j.issn.1000-8578.2024.23.1053
- VernacularTitle:孟德尔随机化探究Omega-3脂肪酸与乳腺癌发病风险的因果关系
- Author:
Jiaqi WANG
1
;
Wei TANG
2
;
Xiao HUANG
1
;
Deyuan FU
3
Author Information
1. Yangzhou University Medical School, Yangzhou 225009, China.
2. Dalian Medical University Graduate School, Dalian 116044, China.
3. Department of Thyroid and Breast Surgery, Subei People's Hospital, Yangzhou 225002, China.
- Publication Type:CLINICALRESEARCH
- Keywords:
Omega-3 fatty acids;
Breast cancer;
Mendelian randomization;
Genome-wide association studies
- From:
Cancer Research on Prevention and Treatment
2024;51(7):567-572
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the causal relationship between Omega-3 fatty acids and the risk of breast cancer via Mendelian randomization analysis. Methods Analysis was conducted on data from genome-wide association studies (GWASs) on Omega-3 fatty acids and breast cancer. The selected instrumental variables (IVs) comprised genetic loci associated with Omega-3 fatty acids. Various Mendelian randomization analysis methods, including inverse-variance weighted (IVW) method, MR–Egger regression analysis, weighted median, simple models, and weighted models, were used to evaluate the causal relationship between Omega-3 fatty acids and the risk of breast cancer. Results A total of 47 single-nucleotide polymorphisms strongly associated with Omega-3 fatty acids were selected as IVs. The analysis methods, including IVW method, revealed no causal relationship between Omega-3 fatty acids and the risk of breast cancer (P>0.05). Analysis methods, such as MR-Egger regression analysis, did not detect significant gene-level pleiotropy (P=0.319), which indicates the high sensitivity and robustness of analysis results. Conclusion The findings of this study suggest the absence of a causal relationship between Omega-3 fatty acids and the risk of breast cancer.
