Circulating Tumor DNA Detection Technology and Its Application Value in Cancer Diagnosis and Treatment
10.16476/j.pibb.2023.0062
- VernacularTitle:循环肿瘤DNA的检测技术及在癌症诊疗中的应用价值
- Author:
Jie-Jie ZHANG
1
;
Chun-Yan NIU
2
;
Lian-Hua DONG
2
;
Yi YANG
2
;
Hui-Jie LI
2
;
Jing-Ya YANG
1
Author Information
1. College of Food Sciences and Technology, Shanghai Ocean University, Shanghai 201306, China
2. Center for Advanced Measurement Science, National Institute of Metrology, Beijing 100029, China
- Publication Type:Journal Article
- Keywords:
circulating tumor DNA;
liquid biopsy;
detection technique;
application;
biomarker
- From:
Progress in Biochemistry and Biophysics
2024;51(2):345-354
- CountryChina
- Language:Chinese
-
Abstract:
Circulating tumor DNA (ctDNA) comes from tumor, reflecting the genetic information of the tumor well, and will change with the progress of tumor. In recent years, the unique capabilities of ctDNA have attracted much attention and been widely studied. In this paper, based on the summary of the source, properties and sample processing of ctDNA, its detection technology and application in cancer diagnosis and treatment are reviewed. The roles and importance of ctDNA reference material in second-generation sequencing are described. The urgency of establishing uniform standards and specifications of ctDNA in various processes, such as samples collection, storage, quantitative testing and data analysis, has been pointed out.
