Circular RNAs Involved in The Development of Nasopharyngeal Carcinoma
10.16476/j.pibb.2023.0110
- VernacularTitle:环状RNA参与鼻咽癌发生发展
- Author:
Si-Cheng ZUO
1
;
Dan WANG
2
;
Yong-Zhen MO
2
;
Yu-Hang LIU
2
;
Jiao-Di CAI
1
;
Can GUO
2
;
Fang XIONG
2
;
Guo-Qun CHEN
1
Author Information
1. Pathology Department, The Fourth Hospital of Changsha, Changsha 410006, China
2. NHC Key Laboratory of Carcinogenesis, Cancer Research Institute, Central South University, Changsha 410078, China
- Publication Type:Journal Article
- Keywords:
nasopharyngeal carcinoma (NPC);
circular RNAs (circRNAs);
Epstein-Barr virus (EBV);
pathogenesis;
biomarker
- From:
Progress in Biochemistry and Biophysics
2024;51(4):809-821
- CountryChina
- Language:Chinese
-
Abstract:
Circular RNAs (circRNAs) are a kind of non-coding RNA (ncRNA) with covalent closed-loop structure. They have attracted more and more attention because of their high stability, evolutionary conservatism, and tissue expression specificity. It has shown that circRNAs are involved in the development of a variety of diseases including malignant tumors recently. Nasopharyngeal carcinoma (NPC) is a malignant tumor that occurs in the nasopharynx and has a unique ethnic and geographical distribution in South China and Southeast Asia. Epstein-Barr virus (EBV) infection is closely related to the development of NPC. Radiotherapy and chemotherapy are the mainstays of treatment for NPC. But tumor recurrence or distant metastasis is the leading cause of death in patients with NPC. Several studies have shown that circRNAs, as gene expression regulators, play an important role in NPC and affect the progression of NPC. This review mainly summarized the research status of abnormally expressed circRNAs in NPC and EBV-encoded circRNAs. We also discussed the possibility of circRNAs as a therapeutic target, diagnostic and prognostic marker for NPC.
