The Effect of Mitochondrial Damage in Chondrocytes on Osteoarthritis
10.16476/j.pibb.2023.0345
- VernacularTitle:软骨细胞线粒体损伤对骨关节炎的影响
- Author:
Zhen-Wei LI
1
;
Jing-Yu HOU
1
;
Yu-Ze LIN
1
;
Zhi-Qi ZHANG
1
;
Shang-Yi LIU
1
;
Xiao-Wen LIU
1
;
Kang-Quan SHOU
1
Author Information
1. Department of Orthopedic, the First College of Clinical Medical Sciences, China Three Gorges University& Yichang Central People’s Hospital, Yichang 443003, China
- Publication Type:Journal Article
- Keywords:
osteoarthritis;
chondrocyte;
mitochondrial damage
- From:
Progress in Biochemistry and Biophysics
2024;51(7):1576-1588
- CountryChina
- Language:Chinese
-
Abstract:
The pathogenesis of osteoarthritis (OA) is related to a variety of factors such as mechanical overload, metabolic dysfunction, aging, etc., and is a group of total joint diseases characterized by intra-articular chondrocyte apoptosis, cartilage fibrillations, synovial inflammation, and osteophyte formation. At present, the treatment methods for osteoarthritis include glucosamine, non-steroidal anti-inflammatory drugs, intra-articular injection of sodium hyaluronate, etc., which are difficult to take effect in a short period of time and require long-term treatment, so the patients struggle to adhere to doctor’s advice. Some methods can only provide temporary relief without chondrocyte protection, and some even increase the risk of cardiovascular disease and gastrointestinal disease. In the advanced stages of OA, patients often have to undergo joint replacement surgery due to pain and joint dysfunction. Mitochondrial dysfunction plays an important role in the development of OA. It is possible to improve mitochondrial biogenesis, quality control, autophagy balance, and oxidative stress levels, thereby exerting a protective effect on chondrocytes in OA. Therefore, compared to traditional treatments, improving mitochondrial function may be a potential treatment for OA. Here, we collected relevant literature on mitochondrial research in OA in recent years, summarized the potential pathogenic factors that affect the development of OA through mitochondrial pathways, and elaborated on relevant treatment methods, in order to provide new diagnostic and therapeutic ideas for the research field of osteoarthritis.
