Tumor Therapy: Targeted Substances Metabolism Reprogramming Induces Tumor Ferroptosis
10.16476/j.pibb.2023.0303
- VernacularTitle:肿瘤治疗：靶向物质代谢重编程诱导铁死亡
- Author:
Jin-Ping ZHANG
1
;
Yue-Qing WANG
1
;
Mo WANG
2
;
Xin-Yue WANG
1
;
Xiao-Qin MOU
1
;
Xi ZHENG
1
;
Chuang CHENG
1
;
Jing HE
1
;
Li-Li ZOU
1
;
Xiao-Wen LIU
1
Author Information
1. Hubei Key Laboratory of Tumor Microenvironment and Immunotherapy & College of Basic Medical Sciences, China Three Gorges University, Yichang 443002, China
2. Hubei Provincial Clinical Research Center for Precise Prevention and Treatment of Elderly Gastrointestinal Cancer, The Second People’s Hospital of China Three Gorges University, Yichang 443002, China
- Publication Type:Journal Article
- Keywords:
tumor therapy;
ferroptosis;
substance metabolism reprogramming
- From:
Progress in Biochemistry and Biophysics
2024;51(7):1540-1550
- CountryChina
- Language:Chinese
-
Abstract:
There are huge differences between tumor cells and normal cells in material metabolism, and tumor cells mainly show increased anabolism, decreased catabolism, and imbalance in substance metabolism. These differences provide the necessary material basis for the growth and reproduction of tumor cells, and also provide important targets for the treatment of tumors. Ferroptosis is an iron-dependent form of cell death characterized by an imbalance of iron-dependent lipid peroxidation and lipid membrane antioxidant systems in cells, resulting in excessive accumulation of lipid peroxide, causing damage to lipid membrane structure and loss of function, and ultimately cell death. The regulation of ferroptosis involves a variety of metabolic pathways, including glucose metabolism, lipid metabolism, amino acid metabolism, nucleotide metabolism and iron metabolism. In order for tumor cells to grow rapidly, their metabolic needs are more vigorous than those of normal cells. Tumor cells are metabolically reprogrammed to meet their rapidly proliferating material and energy needs. Metabolic reprogramming is mainly manifested in glycolysis and enhancement of pentose phosphate pathway, enhanced glutamine metabolism, increased nucleic acid synthesis, and iron metabolism tends to retain more intracellular iron. Metabolic reprogramming is accompanied by the production of reactive oxygen species and the activation of the antioxidant system. The state of high oxidative stress makes tumor cells more susceptible to redox imbalances, causing intracellular lipid peroxidation, which ultimately leads to ferroptosis. Therefore, in-depth study of the molecular mechanism and metabolic basis of ferroptosis is conducive to the development of new therapies to induce ferroptosis in cancer treatment. Ferroptosis, as a regulated form of cell death, can induce ferroptosis in tumor cells by pharmacologically or genetically targeting the metabolism of substances in tumor cells, which has great potential value in tumor treatment. This article summarizes the effects of cellular metabolism on ferroptosis in order to find new targets for tumor treatment and provide new ideas for clinical treatment.
