The Role of Nrf2 in Exercise Improving of NAFLD
10.16476/j.pibb.2023.0274
- VernacularTitle:核因子E2相关因子2在运动改善非酒精性脂肪性肝病中的作用
- Author:
Ge ZHAO
1
;
Yuan LUO
2
;
Ya-Ping LI
3
;
Yan-Qing YAN
1
;
Shu-Jing LIU
4
Author Information
1. School Physical Education Research Center, Guangdong University of Science and Technology, Dongguan 523083, China
2. School of General Education, Guangzhou Institute of Science and Technology, Guangzhou 510540, China
3. Department of Physical Education, Guangzhou Huali College, Guangzhou 511325, China
4. Key Laboratory of Sports Technique, Tactics and Physical Function of General Administration of Sport of China, Guangzhou Sport University, Guangzhou 510500, China
- Publication Type:Journal Article
- Keywords:
exercise;
antioxidant;
Nrf2;
NAFLD
- From:
Progress in Biochemistry and Biophysics
2024;51(5):1079-1089
- CountryChina
- Language:Chinese
-
Abstract:
In cardiovascular disorders, neurological diseases, and chronic metabolic diseases, the nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathway is essential for maintaining cell homeostasis. According to studies, boosting Nrf2 expression can be used to cure or prevent chronic diseases that are characterized by oxidative stress, inflammation, and mitochondrial dysfunction. Nonalcoholic fatty liver disease (NAFLD) is a chronic metabolic liver disease characterized by hepatic steatosis brought on by a number of causes other than alcohol. In recent years, its incidence has gradually risen across the globe. According to relevant studies, NAFLD and the Nrf2 signaling pathway are tightly connected. Inhibiting lipid production and metabolism-related enzymes, repairing impaired liver metabolism, and lowering hepatic lipid storage are all possible with Nrf2 activation. Exercise is a powerful tool for treating and preventing NAFLD. However, exercise type, exercise intensity, environment, and exhaustion all have an impact on the Nrf2 signaling pathway. By activating Nrf2, exercise can lessen liver inflammation, oxidative stress, endoplasmic reticulum stress, and insulin resistance, and ameliorate liver damage to improve NAFLD. The activation of Nrf2 signaling pathway, its associated mechanism of controlling antioxidation, and the impact of exercise on the Nrf2 signaling pathway are all explained in this work. Based on the pathogenesis of NAFLD, this article examines the connection between exercise, Nrf2, and NAFLD, and the current state of knowledge regarding Nrf2’s role in the amelioration of NAFLD through exercise. It offers a theoretical frame of reference for future research into how Nrf2 might be used to improve NAFLD.
