The relationship between plasma D-dimer levels and etiological classification，severity and outcome of acute ischemic stroke
- VernacularTitle:血浆D-二聚体水平与急性缺血性脑卒中病因分型、严重程度及预后的相关性研究
- Author:
Yuming TENG
1
;
Guangsong HAN
1
;
Yuhui SHA
1
Author Information
- Publication Type:Journal Article
- Keywords: Stroke; TOAST; D-dimer; NIHSS score; Functional prognosis
- From: Journal of Apoplexy and Nervous Diseases 2022;39(5):388-393
- CountryChina
- Language:Chinese
- Abstract: To investigate the correlation between plasma D-dimer and subtype，severity and functional prognosis of patients with acute ischemic stroke. Methods The clinical，imaging and laboratory data of patients with acute ischemic stroke were confirmed by clinical and imaging in Peking Union Medical College Hospital from January 2013 to December 2020 were analyzed retrospectively. Results There were 1034 patients with acute ischemic stroke confirmed by clinical and imaging，of which 845 patients completed the detection of plasma D-dimer level within 24 hours and were included in this study. Plasma D-dimer levels was significantly different in different stroke subtypes （P<0.001）. Plasma D-dimer levels was positively correlated with NIHSS score （r=0.166，P<0.001） and mRS score （r=0.125，P<0.001）. Binary regression analysis showed that plasma D-dimer level was associated with poor functional prognosis （unadjusted OR=1.058，95%CI 1.019～1.099；adjusted model 1 OR=1.026，95%CI 1.014～1.091；adjusted model 2 OR=1.022，95%CI 0.984～1.061）. NIHSS score played a full mediation effect between plasma D-dimer level and poor functional prognosis. The sensitivity of plasma D-dimer levels in predicting the prognosis of poor functional prognosis was 54.9%，the specificity was 66.1%，and the area under the receiver operating characteristic （ROC） curve was 0.609.Conclusion We had shown that plasma D-dimer levels are significantly correlated with the etiological classification and severity of acute ischemic stroke，and plasma D-dimer levels may affect the functional prognosis through this correlation. In addition，plasma D-dimer levels can be used to predict poor functional prognosis of acute ischemic stroke.
- Full text:2024072421381912671血浆D-二聚体水平与急性缺血性脑卒中病因分型、_严重程度及预后的相关性研究.pdf
