Study and bioinformatics analysis of miRNA-204 expression in hippocampal tissues of epileptic mice based on gene chip
10.19845/j.cnki.zfysjjbzz.2022.0126
- VernacularTitle:基于基因芯片对癫痫小鼠海马组织miRNA-204表达的研究及生物信息学分析
- Author:
Qiong WU
1
;
Tingting LV
1
;
Limei DIAO
1
Author Information
1. The Xinyang Hospital Affiliated To Zhengzhou University,Xinyang Central Hospital,Xinyang 464000,China
- Publication Type:Journal Article
- Keywords:
Gene chip / Epilepsy;
The miRNA-204;
Wnt pathways;
Bioinformatics analysis
- From:
Journal of Apoplexy and Nervous Diseases
2022;39(6):493-495
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the expression of miRNA-204 in hippocampus of epileptic mice based on gene chip.Methods Differential genes were detected by microarray in hippocampal tissues of epileptic mice,and their target genes were enriched and pathway analyzed by bioinformatics.Results The expression of miRNA-204,a differential gene associated with epilepsy,was down-regulated,and 457 related target genes were predicted.The function of 27 genes (P<0.01) and 16 signaling pathways (P<0.05) were obtained by enrichment analysis.Conclusion Through analysis,the effect of miRNA-204 down-regulation on epileptic mice was clarified,and the miRNA-204 related pathway Wnt was analyzed,laying a foundation for further study on the regulation mechanism of miRNA-204 on epilepsy.
- Full text:2024072421125750269Study and bioinformatics analysis of miRNA-204 expression in hippocampal tissues of epileptic mice based on gene chip.pdf
