Predictive value of cerebral artery stenosis combined with serum Tau protein,Aβ and VILIP-1 in elderly cognitive impairment
10.19845/j.cnki.zfysjjbzz.2022.0178
- VernacularTitle:脑动脉狭窄程度联合血清Tau蛋白、Aβ和VILIP-1检测对老年认知功能障碍的预测价值
- Author:
Jinya HU
1
;
Xiangan MENG
1
;
Yanli LI
1
Author Information
1. Hebei PetroChina Central Hospital,Langfang 065000,China
- Publication Type:Journal Article
- Keywords:
Degree of cerebral artery stenosis;
Tau protein;
β-amyloid;
Cone-like protein-1;
Mild cognitive impairment
- From:
Journal of Apoplexy and Nervous Diseases
2022;39(8):709-712
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigated the predictive value of cerebral artery stenosis combine with serum Tau protein,β-amyloid (Aβ) and cone-like protein-1 (VILIP-1) detection in elderly patients with mild cognitive impairment (MCI).Methods A total of 80 elderly MCI patients (MCI group) who were treated in our hospital from July 2020 to December 2021 were selected,80 Alzheimer’s disease (AD) patients (AD group) and 80 healthy people (Healthy group),the serum Tau protein,Aβ and VILIP-1 levels were compared among the three groups,and the differences in the MMSE score,MOCA score,ADL score,and cerebral artery stenosis between the MCI group and the AD group were also analyzed.Results Serum Tau protein in MCI group was higher than healthy group (P＜0.05).A was lower than healthy group (P＜0.05),VILIP-1 was higher than healthy group (P＜0.05),but lower than AD group (P＜0.05).The MMSE score and MOCA score in the MCI group were higher than AD group (P<0.05).The level of VILIP-1 in MCI group and AD group was negatively correlated with MMSE score and MOCA score (P<0.05).The rate of posterior cerebral artery stenosis in the MCI group was lower AD group (P<0.05).The area under the ROC curve of the posterior cerebral artery stenosis rate combine with VILIP-1 level in predicting MCI was 0.852,which was higher than posterior cerebral artery stenosis rate and VILIP-1 alone (P<0.05).Conclusion Posterior cerebral artery stenosis rate combine with VILIP-1 level has good application value in predicting MCI in the elderly.
- Full text:2024072322453100423Predictive value of cerebral artery stenosis combined with serum Tau protein,Aβ and VILIP-1 in elderly cognitive impairment.pdf
