The prognostic value of eukaryotic cell translation initiation complex 4F in HCC patients
10.19405/j.cnki.issn1000-1492.2022.11.006
- Author:
Renzhe Qian
1
;
Dachen Zhou
1
;
Ziheng Lu
1
;
Liang He
1
;
Shubo Pan
1
;
Bin Zhang
1
Author Information
1. Dept of General Surgery，The Second Affiliated Hospital of Anhui Medical University，Hefei 230601
- Publication Type:Journal Article
- Keywords:
EIF4F;
hepatocellular carcinoma;
prognosis of disease;
protein translation;
Nomogram model
- From:
Acta Universitatis Medicinalis Anhui
2022;57(11):1712-1717
- CountryChina
- Language:Chinese
-
Abstract:
Objective :To study the correlation between eukaryotic translation initiation complex 4f ( EIF4F) and clinical prognosis of patients with hepatocellular carcinoma (HCC) ．
Methods :By following up the clinical data of 743 HCC patients in the specimen bank，94 HCC tissue specimens with complete follow-up information were select- ed，and the clinical data were collected．The paired tissue specimens were made into tissue chip for immunohisto- chemical staining．Image J was used to analyze the optical density value of tissue chip staining，and R4. 0. 5 soft- ware was used to conduct nonparametric test analysis，draw KM curve，Cox regression analysis，and Nomogram sta- tistical analysis on experimental data and follow-up data.
Results :Phosphorylation of 4EBP1 was significantly acti- vated in HCC tissues (P＜0. 001) ，and the activation Phosphorylation of 4EBP1 was associated with the clinical prognosis of HCC patients，P = 0. 038．
Conclusion :The activation of 4EBP1 phosphorylation in tumor tissue pre- dicts shorter overall survival time in HCC patients.
- Full text:2024072322141090856真核细胞翻译起始复合物4F对HCC患者的预后价值_钱仁哲.pdf
