Voxel-based morphometry and ApoE gene detection in the diagnosis of Amnestic mild cognitive impairment
- VernacularTitle:基于体素的MRI形态学测量及ApoE基因检测在遗忘型轻度认知障碍诊断中的应用
- Author:
Tong KANG
1
;
Ying ZHANG
1
;
Yizhi ZHANG
1
Author Information
- Publication Type:Journal Article
- Keywords: Amnestic mild cognitive impairment; Magnetic resonance imaging; Gray matter; Voxel-based morphometry; ApoE gene polymorphism
- From: Journal of Apoplexy and Nervous Diseases 2022;39(9):788-793
- CountryChina
- Language:Chinese
- Abstract: To analyze the characteristics of brain gray matter volume changes and ApoE gene polymorphism in aMCI patients with compared with normal elderly people by voxel-based MRI morphometry and gene detection technology. Exploring the possible correlation in those changes and the pathogenesis of aMCI. Methods Recruiting 14 aMCI patients and 15 normal elderly people who were matched with each other by age，gender，ethnicity，education，living background and determined no blood relationship. To give every case three-dimensional T1WI scan with 3.0T magnetic resonance imaging. We use the SPM12-based DARTEL toolbox to preprocess the structural images obtained from the scan，and then compare voxel-based statistical results of the whole brain gray matter volume of the aMCI group and the control. Detecting the ApoE gene by drawing blood to identify the allele and genotype of the ApoE gene in each sample. The data obtained was analyzed by SPSS20.0 software to calculate the allele frequency and genotype frequency of the three groups of ApoE genes. Results The ε3/ε4 genotype in the group aMCI was significant difference between the aMCI and the control（P<0.05）. Compared with the control，the gray matter atrophy of the aMCI was mainly located in the left insula，superior frontal gyrus,middle frontal gyrus，anterior insula，posteriorcentral gyrus，ventromedial prefrontal lobe，bilateral superior parietal lobule,right angular gyrus. Conclusion ApoE gene polymorphism was associated with the morbidity of patients with aMCI，and ApoEε4 may be a risk factor for aMCI. The thalamus,posterior cingulate cortex were also involved.Gray matter atrophy in patients with aMCI was mainly located in the parietal lobule and the insular.
- Full text:2024072321553422921Voxelbased morphometry and ApoE gene detection in the diagnosis of Amnestic mild cognitive impairment.pdf
