Correlation between SORL1 gene polymorphism and Alzheimer’s disease
- VernacularTitle:SORL1基因多态性与阿尔茨海默病的相关性研究
- Author:
Ruiting BAO
1
;
Lili DAI
1
;
Tao ZHOU
1
Author Information
- Publication Type:Journal Article
- Keywords: Alzheimer’s disease; SORL1 gene; Polymorphism
- From: Journal of Apoplexy and Nervous Diseases 2022;39(9):777-783
- CountryChina
- Language:Chinese
- Abstract: To investigate the relationship between SORL1 gene polymorphism and sporadic Alzheimer’s disease（Alzheimer’s disease，AD）.Methods The SNP loci of SORL1 gene rs1010159，rs2282649，rs3824968，rs1699102，rs3781836，rs2070045，rs3781834，rs641120，rs689021，rs668387 and rs12364988 in 131 sporadic AD patients and 128 healthy controls in Xinjiang were detected by PCR amplification and DNA sequencing. Results There was no significant difference between AD group and control group in the polymorphisms of SNP loci rs1010159，rs2282649，rs3824968，rs1699102，rs3781836，rs2070045，rs3781834，rs641120，rs689021，rs668387，rs12364988 and rs985421 of SORL1 gene（P>0.05）.Conclusion The polymorphisms of SNP loci rs1010159，rs2282649，rs3824968，rs1699102，rs3781836，rs2070045，rs3781834，rs641120，rs689021，rs668387，rs12364988 and rs985421 of SORL1 gene have no correlation with the pathogenesis of AD.
- Full text:2024072321493218586SORL1基因多态性与阿尔茨海默病的相关性研究.pdf
