Effects of salvianolic acid on expression levels of serum GFAP,PGP9.5,IL-5,IL-6,IL-8 and IL-10 and prognosis in patients with acute cerebral infarction
10.19845/j.cnki.zfysjjbzz.2022.0225
- VernacularTitle:丹参多酚酸对急性脑梗死患者血清 GFAP、PGP9.5IL-5、IL-6、IL-8、IL-10表达水平和预后的影响
- Author:
Diqin HE
1
;
Minghao FANG
1
;
Mingmin YU
1
Author Information
1. PLA Clinical College of Anhui Medical University,the 901 Hospital of Joint Logistics Support Force of PLA,Hefei 230031,China
- Publication Type:Journal Article
- Keywords:
Salvianolic acid;
Acute ischemic stroke;
Inflammatory factor;
Glial fibrillary acidic protein
- From:
Journal of Apoplexy and Nervous Diseases
2022;39(10):905-908
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of Salvianolic acid on the expression of glial fibrillary acidic protein (GFAP),protein gene product (PGP9.5),IL-5,IL-6,IL-8,IL-10 and prognosis in patients with acute ischemic stroke.Methods 84 patients with acute ischemic stroke were divided into salvia miltiorrhiza group (n=42) and control group (n=42).Barthel index and NIHSS score were performed on the day of admission and 14 days.The post-infarction volume was calculated and compared after head MRI.The expression levels of serum GFAP,PGP9.5,IL-5,IL-6,IL-8 and IL-10 were detected and compared by magnetic particle chemiluminescence method.The prognosis was determined by modified Rankin score (mRS) 90 days after infarction.Results After treatment,NIHSS score,Barthel index and infarct volume in salvia miltiorrhiza group were significantly decreased (P<0.05),significantly increased (P<0.05) and significantly decreased (P<0.05).GFAP,IL-6 and IL-8 decreased significantly in salvia miltiorrhiza group after treatment compared with the control group (all P<0.05).After treatment,IL-10 expression level in salvia miltiorrhiza group increased more significantly than that in control group (P<0.05).The prognosis of Salvia miltiorrhiza group was better than that of control group (P<0.05).Conclusion Salvianolic acid in the treatment of acute ischemic stroke can effectively inhibit inflammatory reaction,reduce brain injury,improve neurological impairment,improve daily behavior and improve prognosis.
- Full text:2024072320523503756Effects of salvianolic acid on expression levels of serum GFAP,PGP9.5,IL-5,IL-6,IL-8 and IL-10 and prognosis in patients with acute cerebral infarction.pdf
