Overexpression and clinical significance of PBX3 in acute myeloid leukemia
10.19405/j.cnki.issn1000-1492.2022.12.028
- Author:
Hui Zhang
1
;
Zixiang Chen
2
;
Chunyi Zhao
2
;
Qixiang Shao
2
;
Yangjing Zhao
2
Author Information
1. Dept of Clinical Laboratory，The Affiliated Hospital of Jiangsu University ，Zhenjiang 212001
2. Dept of Laboratory Medicine，School of Medicine，Jiangsu University，Zhenjiang 212013
- Publication Type:Journal Article
- Keywords:
acute myeloid leukemia;
pre-B-cell leukemia homologous box 3;
homeobox gene;
prognostic marker
- From:
Acta Universitatis Medicinalis Anhui
2022;57(12):2012-2018,2024
- CountryChina
- Language:Chinese
-
Abstract:
Objective :To investigate the expression levels and potential clinical significance of pre-B-cell leukemia homologous box 3 (PBX3) in bone marrow samples from acute myeloid leukemia (AML) .
Methods :The mRNA expression levels of PBX3 were determined by bioinformatics which analyzed the RNAseq data of 33 malignancies from the cancer genome atlasdatabase． (TCGA) The correlations among the expression levels of PBX3，the clinical parameters and prognosis of AML patients were further analyzed．The differentially expressed genes in the whole transcriptome were analyzed to identify the molecular network in AML caused by PBX3 expression abnormalities.
Results :The mRNA expression levels of PBX3 were up-regulated in 12 malignancies，and the altitudes increased most significantly in AML than any other cancer types．Patients with high PBX3 expression showed shorter overall survival and disease-free survival than patients with low PBX3 expression．High PBX3 expression was significantly associated with FLT3，NPM1，and DNMT3A mutation．PBX3 expression was positively correlated with multiple ho- meobox genes (including most HOXA and HOXB genes ，MEIS1 ) ，and the expression levels of these homeobox genes were all negatively correlated with AML patients overall survival．
Conclusion :PBX3 high expression in the bone marrow of AML patients is a potential biomarker for poor prognosis ，and it may have extensive interactions with other homeobox genes.
- Full text:2024072222443819796PBX3在急性髓系白血病中的高表达及其临床意义_张慧.pdf
