Spatial and temporal heterogeneity of pathological phenotype of EGFR - mutant transformed locally advanced or metatsatic small-cell lung cancer or neuroendocrine carcinoma
10.19405/j.cnki.issn1000-1492.2022.12.023
- Author:
Shiling Zhang
1
,
2
,
3
;
Chanyuan Zhang
1
,
2
,
3
;
Yuqing Chen
2
,
3
,
4
;
Jinj Yang
1
,
2
,
3
Author Information
1. The Second School of Clinical Medicine，Southern Medical University，Guangzhou 510515
2. Guangdong Lung Cancer Institute，Guangdong Provincial Key Laboratory of Translational Medicine in Lung Cancer，Guangdong Provincial People '
3. s Hospital，Guangdong Academy of Medical Sciences，Guangzhou 510080
4. School of Medicine，South China University of Technology，Guangzhou 510006
- Publication Type:Journal Article
- Keywords:
EGFR mutation;
small-cell lung cancer;
neuroendocrine carcinoma;
histological transformation;
spa- tial and temporal heterogeneity
- From:
Acta Universitatis Medicinalis Anhui
2022;57(12):1985-1990
- CountryChina
- Language:Chinese
-
Abstract:
Objective :To explore the spatial and temporal heterogeneity of pathological phenotype of epidermal growth factor receptor (EGFR) -mutant transformed locally advanced or metastatic small-cell lung cancer( SCLC) or neuroendocrine carcinoma (NEC) ．
Methods :This study retrospectively analyzed EGFR-mutant LUAD patients who were treated with EGFR-TKIs and underwent a transformation into SCLC / NEC． Baseline clinicopathological characteristics after initial transformation were summarized．According to the different pathological components of initial SCLC / NEC transformation，it was defined as incomplete transformation and complete transformation．Incom- plete transformation was defined as three categories : intratumoral transformation，intertumoral transformation and ef- fusional transformation.
Results :This study collected 49 patients who met the criteria．Among forty-nine patients， incomplete transformation was 34. 7% ( 17 /49) and complete transformation was 65. 3% (32 /49) ．In addition， intratumoral transformation ，intertumoral transformation and effusional transformation were respectively 82. 3% ( 14 /17) ，5. 9% ( 1 /17) and 11. 8% (2 /17) . It was mean that the spatial heterogeneity of pathological phenotype of initially transformed SCLC / NEC was 34. 7%．After initial transformation，among the fifteen patients in dynamic histological and / or cytological biopsies，the temporal heterogeneity of pathological phenotype of initially transformed SCLC / NEC was 46. 7% (7 /15) ．In addition，there was no significant difference in first-line treatment post-trans- formation progression-free survival and post-transformation overall survival between incomplete transformation group and complete transformation group．
Conclusion : EGFR-mutant transformed locally advanced or metaststic SCLC / NEC has spatial and temporal heterogeneity in pathological phenotype.
- Full text:2024072222204193939EGFR突变转化型晚期小细...分泌癌的病理表型时空异质性_张仕灵.pdf
