Associations of polymorphism in large tumor suppressor kinase 2 gene with colorectal cancer
10.19405/j.cnki.issn1000-1492.2022.12.014
- Author:
Yingze Li
1
;
Fang Gao
2
;
Xingru Wei
1
;
Wenjie Dong
1
;
Licong Ma
3
;
Tong Dang
3
;
Yanbin Jia
1
,
3
,
4
Author Information
1. Dept of Basic Medicine and Forensic Medicine，Baotou Medical College，Baotou 014060
2. College of Medical Technology and Anaesthesia，Baotou Medical College，Baotou 014060
3. Inner Mongolia Institute of Digestive Diseases，The Second Affiliated Hospital of Baotou Medical College，Baotou 014030
4. School of Nursing，Baotou Medical College，Baotou 014060
- Publication Type:Journal Article
- Keywords:
large tumor suppressor kinase 2;
colorectal cancer;
single nucleotide polymorphism;
association study
- From:
Acta Universitatis Medicinalis Anhui
2022;57(12):1927-1932
- CountryChina
- Language:Chinese
-
Abstract:
Objective :To investigate the association between single nucleotide polymorphism ( SNP) rs558614， rs9552315，rs7317471 and rs9509492 in large tumor suppressor kinase 2 (LATS2) gene and the risk of colorectal cancer．
Methods :A total of 390 colorectal cancer patients and 413 healthy subjects were genotyped by Taqman method．The odds ratio ( OR) and its 95% CI were calculated by unconditional logistic regression，to estimate the associations between SNP rs558614，rs9552315，rs7317471，rs9509492 in LATS2 gene and the risk of colorectal cancer，rectal cancer，as well as colon cancer under codominant，dominant，recessive，overdominant，and log-ad- ditive genetic models． Haplotypes were constructed by haploview software 4. 2 .
Results :SNP rs558614， rs7317471，rs9552315 and rs9509492 in LATS2 gene were not associated with the risk of colorectal cancer，rectal cancer and colon cancer under codominant，dominant，recessive，overdominant，and log-additive genetic models. No haploid blocks were formed between the 4 SNPs．
Conclusion :SNP rs558614 ，rs7317471 ，rs9552315， rs9509492 in LATS2 gene may not play a major role in the development of colorectal cancer，rectal cancer and co- lon cancer.
- Full text:2024072116291695729大肿瘤抑制激酶2基因多态性与原发性结直肠癌的关联性_李迎泽.pdf
