Diagnostic accuracy of 68Ga-PSMA PET hybrid imaging in evaluating treatment response to 177Lu-PSMA radioactive ligand therapy in patients with advanced metastatic prostate cancer: A systematic review and meta-analysis.
- Author:
Timothy James O. Lam
1
;
Arrene Joy B. Baldonado
1
;
Dominic N. Velasco
1
Author Information
- Publication Type:Journal Article
- Keywords: PET; PSMA; treatment response
- MeSH: Gallium; lutetium; prostatic neoplasms
- From: The Philippine Journal of Nuclear Medicine 2024;19(1):8-16
- CountryPhilippines
- Language:English
-
Abstract:
INTRODUCTION:68Ga-PSMA PET is an effective imaging modality in the evaluation of prostate cancer. However, there is limited data on its use in the evaluation of therapeutic response, particularly in radioligand therapy.
OBJECTIVE:Our aim is to investigate the diagnostic accuracy of 68Ga-PSMA PET hybrid imaging in evaluating response to 177Lu-PSMA therapy in patients with mCRPC compared with the standard use of serum PSA.
METHODOLOGY:A systematic review was done according to the Cochrane diagnostic accuracy reviews guidelines and the PRISMA checklist of literature from January 2015 to August 2020. Literature search, study selection, and data extraction were conducted by 2 reviewers. Statistical analysis of data was done using Meta-DiSc v1.4
RESULTS:A total of 5 studies were included following screening. A total of 128 patients were included in the review. Using PSA response as the reference standard, the pooled sensitivity and specificity of 68Ga-PSMA PET hybrid imaging to evaluate treatment response to 177Lu-PSMA therapy was 85% (Cl: 74 to 92%) and 74% (Cl: 62 to 84%), respectively. The computed diagnostic accuracy was 79.7%.
CONCLUSION:68Ga-PSMA PET hybrid imaging is an effective diagnostic procedure in evaluating treatment response to 177Lu-PSMA therapy ligand therapy with good sensitivity, specificity, and diagnostic accuracy. - Full text:2024072309510717864100133.pdf
