Mechanism of action of follicular helper T cells in autoimmune hepatitis

Longlong Luo; Lifei Wang; Guojing Xing; Ying Zheng; Lixia LU; Chuyi LI; Bin LI; Jun MA; Xiaohui YU; Jiucong Zhang

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Mechanism of action of follicular helper T cells in autoimmune hepatitis

VernacularTitle:滤泡辅助性T淋巴细胞在自身免疫性肝炎中的作用机制
Author: Longlong LUO ¹ ; Lifei WANG ¹ ; Guojing XING ¹ ; Ying ZHENG ¹ ; Lixia LU ¹ ; Chuyi LI ¹ ; Bin LI ¹ ; Jun MA ² ; Xiaohui YU ¹ ; Jiucong ZHANG ¹
Author Information

1. Department of Gastroenterology, Gansu Provincial Key Laboratory of Stem Cells and Genetic Drugs, The 940 Hospital of Joint Logistic Support Force of PLA， Lanzhou 730050， China
2. Basic Medical Laboratory, Gansu Provincial Key Laboratory of Stem Cells and Genetic Drugs ,The 940 Hospital of Joint Logistic Support Force of PLA， Lanzhou 730050， China
Publication Type:Review
Keywords: Hepatitis， Autoimmune; T Follicular Helper Cells; T-Lymphocytes， Regulatory; B-Lymphocytes
From: Journal of Clinical Hepatology 2024;40(7):1466-1469
CountryChina
Language:Chinese
Abstract: Autoimmune hepatitis （AIH） is a type of chronic hepatitis caused by the attack of hepatocytes by the autoimmune system， and with the prolongation of disease course， it may gradually progress to liver cirrhosis and even hepatocellular carcinoma. Although great achievements have been made in the understanding and treatment of AIH， its etiology and pathogenesis still remain unclear. T cells play a crucial role in the development and progression of AIH， and by focusing on follicular helper T cells， this article elaborates on the research advances in follicular helper T cells in AIH， in order to provide new ideas and strategies for the clinical treatment of AIH.