Role of lipophagy in the prevention and treatment of nonalcoholic fatty liver disease
- VernacularTitle:脂肪自噬在非酒精性脂肪性肝病防治中的作用
- Author:
Zhili XIAO
1
;
Chenxia LU
2
;
Danni ZHOU
2
;
Zhuangzhuang CHEN
1
;
Mingzhong XIAO
1
;
Xiaodong LI
2
Author Information
- Publication Type:Review
- Keywords: Non-alcoholic Fatty Liver Disease; Autophagy; Therapeutics
- From: Journal of Clinical Hepatology 2024;40(7):1450-1458
- CountryChina
- Language:Chinese
- Abstract: Nowadays， the prevalence of nonalcoholic fatty liver disease （NAFLD） is constantly rising in China and globally， and its incidence rate is increasing year by year， which has seriously affected human life and health. Lipophagy is molecular chaperone-mediated autophagy and has the functions of promoting lipolysis， maintaining the lipid homeostasis of hepatocytes， and alleviating hepatocyte fatty degeneration. Lipophagy has three main processes of lipid droplet catabolism， lipid droplet autophagy， and fatty acid β-oxidation， which are regulated by key genes， receptors， and enzymes. Currently， important advances have been achieved for the intervention methods of traditional Chinese medicine， Western medicine， diet， and exercise in the research on lipophagy， which provides new perspectives for the prevention and treatment strategies for NAFLD.
