Predictive value of apolipoprotein B to apolipoprotein A-Ⅰ ratio combined with carotid intima media thickness in acute cerebral infarction
- VernacularTitle:载脂蛋白B与载脂蛋白A-Ⅰ比值联合颈动脉内膜-中层厚度预测急性脑梗死价值研究
- Author:
Junxin KUANG
1
;
Zhiqiang LIU
1
;
Dengfeng HAN
1
Author Information
- Publication Type:Journal Article
- Keywords: Cerebral infarction; Apolipoprotein B to apolipoprotein A Ⅰ ratio; Intima media thickness
- From: Journal of Apoplexy and Nervous Diseases 2022;39(11):970-976
- CountryChina
- Language:Chinese
- Abstract: To investigate the value of apolipoprotein B to apolipoprotein AⅠ ratio combined with carotid intimamedia thickness in predicting acute cerebral infarction.Methods Patients with acute large artery atherosclerotic cerebral infarction in the anterior circulation who were hospitalized in the Department of Neurology，The First Affiliated Hospital of Xinjiang Medical University from July 2020 to June 2021 were selected as the case group.Patients with noncardiovascular and cerebrovascular diseases who were hospitalized during the same period were randomly selected as the control group.The clinical data and laboratory results of the two groups were compared，and the risk factors of acute cerebral infarction were analyzed.To explore the predictive value of apolipoprotein B to apolipoprotein AⅠratio combined with carotid intimamedia thickness in the incidence of cerebral infarction.The clinical data and laboratory results of the two groups were compared.The influencing factors of acute cerebral infarction were analyzed by logistic regression.The receiver operating characteristic curve was used to analyze the predictive value of the ratio of apolipoprotein B to apolipoprotein AⅠcombined with carotid intimamedia thickness in the incidence of cerebral infarction.Results The study included 143 patients with acute cerebral infarction and 122 patients with noncardiovascular and cerebrovascular diseases.Multivariate analysis showed that smoking（OR=3.448，95%CI 1.609-7.391），diabetes（OR=2.884，95%CI 1.389-5.989），carotid intimamedia thickness （OR=1.633，95%CI 1.219-2.189），Leukocytes （OR=1.258，95%CI 1.036-1.527），free fatty acids（OR=14.113，95%CI 1.942-102.558），ratio of apolipoprotein B to apolipoprotein AI（OR=10.896，95%CI 2.290-51.846），D Dimer（OR=4.690，95%CI 2.097-10.488），homocysteine（OR=9.594，95%CI 1.112-82.772） were independent risk factors for large atherosclerotic cerebral infarction.The value of the ratio of apolipoprotein B to apolipoprotein AⅠ [JP3]and carotid intimamedia thickness in predicting acute cerebral infarction was analyzed by receiver operating characteristic curve.The results showed that the area under the curve was 0.757（95%CI 0.699-0.816），the best predictive value was 0.466，the sensitivity was 81.8%，and the specificity was 58.2%.Conclusion The ratio of apolipoprotein B to apolipoprotein AⅠ and the carotid intimamedia thickness are related to the atherosclerotic cerebral infarction of the anterior circulation large arteries，and they have a certain value in jointly predicting the incidence of cerebral infarction.
- Full text:2024071822454108827Predictive value of apolipoprotein B to apolipoprotein A-Ⅰ ratio combined with carotid intimamedia thickness in acute cerebral infarction.pdf
