The application of left ventricular global longitudinal strain in predicting early cardiotoxicity in breast cancer patients undergoing chemotherapy
10.19405/j.cnki.issn1000-1492.2023.03.023
- Author:
Xiaolin Wen
1
;
Ling Wang
1
;
Jianqiong Chen
2
;
Chaoxue Zhang
1
Author Information
1. Dept of Ultrasound，The First Affiliated Hospital of Anhui Medical University，Hefei 230022
2. Dept of Medical Oncology，The First Affiliated Hospital of Anhui Medical University，Hefei 230022
- Publication Type:Journal Article
- Keywords:
breast cancer;
anthracycline chemotherapy;
speckle tracking imaging;
chemotherapy related cardiotoxicity
- From:
Acta Universitatis Medicinalis Anhui
2023;58(3):486-489
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the value of left ventricular global longitudinal strain( LVGLS) in predicting early chemotherapy related cardiotoxicity in breast cancer patients after chemotherapy．
Methods :Eighty-six breast cancer patients were enrolled in this study and received 6 cycles of doxorubicin + cyclophosphamide．Conventional echocardiography parameters were measured before chemotherapy ( T0 ) ，immediately after chemotherapy ( T1 ) ，6 months(T2) and 12 months after chemotherapy ( T3 ) ． LVGLS was obtained by 2D speck tracing imaging (2DSTI) ，and the relative change of LVGLS( △LVGLS) was calculated at T1．With the occurrence of cardiotoxicity as
the clinical outcome，receiver operating characteristic ( ROC) curve was plotted．The parameters were analyzed at T1 to evaluate the value of △LVGLS in predicting cardiotoxicity.
Results:① Although the change in LVEF was not different between T0 and T1 (P ＞0. 05) ，LVEF decreased significantly at T2 and T3 (P ＜0. 05) . ② Compared with T0，LVGLS decreased at T1，which was further damaged at T2 and T3 (P＜0. 05) . ③ Seven patients (8. 1% ) developed chemotherapy-related cardiotoxicity．LVGLS and △LVGLS were correlated with cardiotoxicity at T1 stage ，and △LVGLS was more significant ( r = 0. 64，P ＜0. 001 ) . ROC curve analysis showed that a △LVGLS ＞12% at T1 predicted cardiotoxicity，with sensitivity of 92. 2% ，specificity of 76% ，and area under the curve was 0. 88.
Conclusion :The LVGLS decreased earlier than LVEF in breast cancer patients after doxorubicin treatment. △LVGLS ＞12% is a good predictor of cardiotoxicity in patients with breast cancer.
- Full text:2024071719120558447左室整体纵向应变在早期预测...癌化疗患者心脏毒性中的应用_闻小林.pdf
