Progress on pharmaceutical characteristics of potassium-competitive acid blocker

VernacularTitle:钾离子竞争性酸阻滞剂的药学特征研究进展
Author: Yaozhen WANG ^{1
,

2} ; Can XU ; Shunli LV ; Jing TIAN ; Dongwei ZHANG
Author Information

1. 海军军医大学第一附属医院药学部,上海 200433
2. 吉林大学白求恩第二医院药学部,吉林长春 130041
Keywords: potassium-competitive acid blocker; acid-related diseases; progress
From: Journal of Pharmaceutical Practice and Service 2024;42(7):278-284
CountryChina
Language:Chinese
Abstract: As a new class of acid inhibitors,potassium-competitive acid blocker(P-CAB)inhibits the conformational transition of H+,K+-ATPase with subsequent suppression of H+,K+exchanging by binding reversibly near the K+binding site of H+,K+-ATPase,which results in the inhibition of gastric acid secretion in a K+-competitive manner.The unique structure and novel mechanism of P-CAB contribute to the pharmaceutical characteristics superior to other PPIs,making it a new alternative for acid-related diseases(ARDs).Progress on pharmaceutical characteristics of P-CAB were reviewed in this paper.