Research progress of vascular endothelial growth factor in the mechanism of blood-retinal barrier damage by diabetic retinopathy
10.3980/j.issn.1672-5123.2024.8.15
- VernacularTitle:VEGF在糖尿病视网膜病变破坏血-视网膜屏障机制中的研究新进展
- Author:
Suhan WANG
1
,
2
,
3
;
Leying ZHANG
1
,
2
,
3
;
Tingting QIN
1
,
2
,
3
;
Jiaojiao WANG
1
,
2
,
3
;
Zongming SONG
1
,
2
,
3
Author Information
1. Henan University People's Hospital
2. Henan Provincial People's Hospital
3. Henan Eye Hospital, Zhengzhou 450003, Henan Province, China
- Publication Type:Journal Article
- Keywords:
diabetic retinopathy;
blood-retinal barrier;
vascular endothelial growth factor(VEGF)
- From:
International Eye Science
2024;24(8):1260-1265
- CountryChina
- Language:Chinese
-
Abstract:
Diabetic retinopathy(DR)is one of the common causes of visual impairment and blindness in adults, which is caused by various pathogenesis. Although the mechanism of DR has not been elucidated yet, the destruction of blood-retinal barrier is a key process. As a highly endothelial-specific factor in promoting the growth of vascular endothelial cell, vascular endothelial growth factor(VEGF)plays a crucial role in the formation of pathological retinal neovascularization and the destruction of blood-retinal barrier. Therefore, a comprehensive understanding of the etiology and pathogenesis of blood-retinal barrier damage promoted by VEGF is critical for exploring the pathogenesis of DR. In this study, the underlying relationship between VEGF and the mechanism of blood-retinal barrier damage, including retinal vascular endothelial cell permeability, vascular inflammatory response, apoptosis, oxidative stress, mitochondrial damage and endoplasmic reticulum stress, with a view to providing a reference for the study in VEGF in the pathogenesis of blood-retinal barrier damage in DR.
