Impact of radioactive impurity nuclides in 90Y microspheres on the therapeutic dose of pancreatic tumors
10.13491/j.issn.1004-714X.2024.03.003
- VernacularTitle:90Y微球中放射性杂质核素对胰腺肿瘤治疗剂量的影响
- Author:
Wen LUO
1
;
Jinsen GUO
1
;
Wei WANG
1
;
Ling CHEN
1
Author Information
1. China Institute of Atomic Energy, Beijing 100023 China.
- Publication Type:OriginalArticles
- Keywords:
90Y Glass microspheres;
Impurity nuclide;
Pancreatic cancer;
Dose calculation
- From:
Chinese Journal of Radiological Health
2024;33(3):242-247
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effects of radioactive impurity nuclides in 90Y glass microsphere on therapeutic dose during radioembolization of pancreatic cancer. To provide a reference for correction of the dose calculated for individuals with different pancreatic tumors. Methods In this study, the radioactive impurity nuclide composition of 90Y glass microsphere samples was analyzed to determine the source term of Monte Carlo calculation. Then, according to the PET/CT medical imaging data of pancreatic cancer patients, the three-dimensional modeling software Solidworks 2020 was used to construct the real and personalized digital human digestive system model of pancreatic cancer patients at a resolution showing the vascular distribution in pancreas and tumor. Finally, the Monte Carlo program GATE 8.2 was used to simulate the three-dimensional radiation dose fields of radioactive impurity nuclides 91Y and 65Zn from 90Y glass microspheres in various tissues and organs. The three-dimensional dose fields were visualized to analyze the influence of radioactive impurity nuclides on therapeutic dose. Results The three-dimensional radiation dose fields of 91Y and 65Zn from 90Y glass microspheres demonstrated two dose extreme points. The maximum dose value of 91Y to tissue was 0.272 mGy and the maximum dose value of 65Zn to tissue was 9.34 μGy, with average statistical errors of less than 3.2%. Conclusion The impact of radioactive impurity nuclides 91Y and 65Zn in 90Y glass microsphere sample on therapeutic dose is minimal and can be neglected.
