Safety and Efficacy of Topiramate Monotherapy in Children with Recent-onset Seizures.
- Author:
Woo Saeng PARK
1
;
Chang Woo KIM
;
Sung Pa PARK
;
Soon Hak KWON
Author Information
1. Department of Pediatrics, School of Medicine, Kyung-pook National University, Taegu, Korea. ppwwss@medigate.net
- Publication Type:Original Article ; Randomized Controlled Trial
- Keywords:
Topiramate monotherapy;
Recent-onset seizures
- MeSH:
Child*;
Epilepsy;
Humans;
Seizures*
- From:Journal of Korean Epilepsy Society
2001;5(1):65-69
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: To investigate the efficacy and safety of topiramate monotherapy in children with recent-onset seizures. METHODS: An open-label, randomized, parallel group trial compared the efficacy and tolerability of topiramate monotherapy versus oxcarbazepine monotherapy in 54 children with newly diagnosed epilepsy. RESULTS: Of the 54 patients treated with topiramate (N=25) or oxcarbazepine (N=29), 51 patients completed the full study period of 16 weeks. In topiramate group, 64% became seizure free, 20% demonstrated a greater than 50% degree in seizure frequency, and 4% got worsened in seizure frequency. In oxcarbazepine group, 59% became seizure free, 24% experienced a greater than 50% reduction in seizure frequency. The efficacy was not statistically different between the two groups. Adverse events were usually only mild to moderate and the tolerability of therapy was similar between the two groups. CONCLUSION: Topiramate monotherapy was highly effective in controlling seizures of children with newly diagnosed epilepsy (seizure free rate : 64%).
