Re-understanding of the clinical application value of dopamine in kidney transplantation
10.3969/j.issn.1674-7445.2024030
- VernacularTitle:多巴胺在肾移植术中临床应用价值的再认识
- Author:
Yuqi ZHONG
1
;
Yuchen WANG
;
Yun MIAO
Author Information
1. 510060 广州,中山大学肿瘤防治中心麻醉科
- Keywords:
Kidney transplantation;
Vasoactive drug;
Dopamine;
Low dose;
Norepinephrine;
Renal perfusion;
Arrhythmias;
Acute kidney injury
- From:
Organ Transplantation
2024;15(4):643-647
- CountryChina
- Language:Chinese
-
Abstract:
Dopamine is the precursor of biosynthesis of norepinephrine.Low-dose dopamine mainly excites dopamine receptors,which may dilate renal and mesenteric vessels,increase renal blood flow and improve the microcirculation.In recent years,low-dose dopamine has been widely applied in the field of kidney transplantation due to its vasoactive effect.However,with the development of evidence-based medicine,the role of dopamine in protecting the perfusion function of renal allograft in kidney transplantation has been questioned.Multiple studies have shown that dopamine brings no significant benefit to renal and cardiac function in kidney transplantation,exerts low pressor effect,and may even increase the risk of perioperative complications.Norepinephrine may be used as a safe substitute.In this article,recent progress in the effect of dopamine upon renal and cardiac function and hemodynamics during kidney transplantation was reviewed,aiming to provide reference for clinical application of dopamine in kidney transplantation.
