Effect of preoperative metabolic syndrome on early function of renal allografts in kidney transplant recipients
10.3969/j.issn.1674-7445.2024045
- VernacularTitle:肾移植受者术前合并代谢综合征对早期移植肾功能的影响
- Author:
Yongbin TANG
1
,
2
;
Zijian TIAN
2
;
Zhipeng ZHANG
3
;
Jinfu WANG
3
;
Ming LIU
1
,
2
;
Yaqun ZHANG
2
Author Information
1. Department of Urology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing 100730, China
2. .
3. Department of Urology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing 100730, China.
- Publication Type:OriginalArticle
- Keywords:
Kidney transplantation;
Metabolic syndrome;
Obesity;
Blood glucose;
Blood lipid;
Delayed graft function;
Serum creatinine;
Estimated glomerular filtration rate
- From:
Organ Transplantation
2024;15(4):607-613
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effect of preoperative metabolic syndrome on early function of renal allografts in allogeneic kidney transplant recipients. Methods Clinical data of 117 kidney transplant recipients were retrospectively analyzed. According to the renal allograft function, they were divided into the delayed graft function (DGF) group (n=29) and non-DGF group (n=88). Relevant risk factors of DGF in recipients undergoing allogeneic kidney transplantation were assessed by univariate and multivariate regression analyses. The effect of preoperative metabolic syndrome on early function of renal allografts was analyzed. Results Among 117 kidney transplant recipients, 47 cases were complicated with preoperative metabolic syndrome, and 29 cases developed postoperative DGF. In the DGF group, 83% of the recipients were complicated with preoperative metabolic syndrome, higher than 74% in the non-DGF group (P<0.05). Univariate analysis showed that the body mass index (BMI) and terminal serum creatinine (Scr) level of the donors, and BMI, blood glucose level, triglyceride level and the proportion of preoperative metabolic syndrome of the recipients in the DGF group were higher than those in the non-DGF group (all P<0.05). Multivariate logistic regression analysis revealed that high Scr levels of the donors, high hemoglobin levels of the recipients and preoperative metabolic syndrome of the recipients were the independent risk factors for DGF after kidney transplantation (all P<0.05). Conclusions Preoperative metabolic syndrome is an independent risk factor for DGF in allogeneic kidney transplant recipients. Corresponding measures should be taken to lower the incidence of DGF and other metabolic complications.
