Research progress in adult liver retransplantation
10.3969/j.issn.1674-7445.2024040
- VernacularTitle:成人再次肝移植研究进展
- Author:
Ruolin WU
1
;
Hongchuan ZHAO
1
;
Xiaoping GENG
1
Author Information
1. Department of Hepatobiliary Pancreatic and Transplantation Surgery, the First Affiliated Hospital of Anhui Medical University, Hefei 230022, China.
- Publication Type:Editorial
- Keywords:
Liver retransplantation;
Liver graft failure;
Living donor liver transplantation;
Immunosuppression;
Immune induction;
Rejection;
Surgical complication;
Disease recurrence
- From:
Organ Transplantation
2024;15(4):563-569
- CountryChina
- Language:Chinese
-
Abstract:
Liver retransplantation is the final option for graft failure after liver transplantation. The interval between the first and second liver transplantation will directly affect surgical indications, technical difficulties and treatment outcomes of adult liver retransplantation. Previous studies have shown that the overall survival of liver allografts and recipients after liver retransplantation is significantly lower than that after the first liver transplantation. However, with comprehensive progress in organ preservation methods, anesthesia management concepts, intensive care strategies, surgical techniques and new immunosuppressive drugs, clinical efficacy of adult liver retransplantation has been significantly improved. In this article, the changes of indications, timing of operation, long-term efficacy and its influencing factors, technical difficulties, selection of immunosuppressive regimens and the implementation of living donor liver retransplantation were reviewed, and the achievements, challenges and potential solutions of adult liver retransplantation were summarized, aiming to provide reference for enhancing clinical efficacy of adult liver retransplantation.
