Clinical characteristics analysis of recurrent pregnancy loss with different modes of fertilization
10.19405/j.cnki.issn1000-1492.2023.02.022
- Author:
Yingming He
1
,
2
,
3
;
Zhehui Zhang
4
;
Yinshuang Xue
4
;
Yue Huang
4
;
Zhenran Liu
4
;
Pin Zhang
4
;
Huifen Xiang
4
Author Information
1. Dept of Obstetrics and Gynecology，The First Affiliated Hospital of Anhui Medical University，Hefei 230012
2. Anhui Public Health Clinical Center，Hefei 230012
3. 3 Dept of Obstetrics and Gynecology
4. The First Affiliated Hospital of Anhui Medical University，Hefei 230022
- Publication Type:Journal Article
- Keywords:
recurrent pregnancy loss;
biochemical pregnancy;
in vitro fertilization and embryo transfer;
clinical characteristics
- From:
Acta Universitatis Medicinalis Anhui
2023;58(2):297-301
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the difference of clinical characteristics of recurrent spontaneous abortion (RSA) in patients with losses after spontaneous gestation and after in vitro fertilization and embryo transfer ( IVFET) ．
Methods :237 patients diagnosed with RSA were divided into spontaneous gestation group ( n = 185) and IVF group (n = 52) according to their previous modes of fertilization．The clinical characteristics of the two groups were analyzed.
Results:Compared with the spontaneous gestation group，the age of the first pregnancy and the age at the time of RSA in the IVF group were statistically greater than those in the natural pregnancy group ( P < 0. 05 ) ．The number of biochemical pregnancies in IVF group was statistically higher than that in spontaneous gestation group，and the number of spontaneous abortions in IVF group was statistically lower than that in spontaneous gestation group (P＜0. 001) ．The proportion of patients with irregular menstruation in IVF group was statistically higher than that in spontaneous gestation group ( P ＜ 0. 05 ) ． The serum activated partial prothrombin time (APTT) ，R , K，high density lipoprotein cholesterol (HDL-C) ，thyrotropin (TSH) and homocysteine ( HCY) in IVF group were statistically lower than those in spontaneous gestation group，and the Angel，Ma，low density lipoprotein cholesterol (LDL-C) and body mass index (BMI) in IVF group were statistically higher than those in spontaneous gestation group (P＜0. 05) ．In the comparison of etiological composition between the two groups，the proportion of anatomical factors in IVF group was statistically higher than that in spontaneous gestation group (P < 0. 05) ．
Conclusion:The abortion risk factors in RSA patients after IVF-ET is more serious than that in RSA patients after natural pregnancy．It is suggested to further improve and implement the pre-pregnancy examination and education of infertile patients during IVF-ET treatment，so as to reduce the risk of RSA and obtain a better pregnancy outcome.
- Full text:2024071422465894079不同受孕方式复发性流产患者的临床特征分析_何英明.pdf
